https://revistas.uautonoma.cl/index.php/ijmss/issue/feed International Journal of Medical and Surgical Sciences 2021-03-18T06:12:15+00:00 Dr. Iván Suazo ijmss@uautonoma.cl Open Journal Systems <p><strong>International Journal of Medical and Surgical Sciences</strong>, (IJMSS) is a serial and peer-review publication, ascribed by the Faculty of Health Sciences and administered by the Vice-Rector's Office for Research and Postgraduate Studies of the Universidad Autónoma de Chile. IJMSS has an international scope, is open access and uses a License Creative Commons of Recognition -Non-Commercial-without derivatives 4.0 International (CC BY-NC-ND 4.0). The contents are available in open access immediately after being published.</p> <p><strong>Objective</strong>: To publish original research papers within the medical and surgical sciences, on all basic scientific aspects of structure, chemistry, developmental biology, physiology and pathology of relevant tissues, microbiology, biomaterials, and behavioral sciences. In general, analytical studies are preferred to descriptive ones.</p> <p><strong>Vision</strong>: IJMSS seeks to be a space for academic discussion and multidisciplinary dialogue in the area of biomedical, medical and surgical sciences in all its aspects, which contributes to scientific communication between research peers and academics in the area.</p> <p><strong>Aimed to</strong> professionals and academics in the field of medical and surgical sciences, health administration, and related specialties.</p> <p>The Journal Publishes in continuous publication schema (four issues per year), original articles, reviews, short communications and letters to the editor in English and Spanish. The IJMSS has <strong>no article processing charges (APC)</strong> or article submission charges for any of the editorial processes or publication.</p> <p><strong>e-ISSN</strong> 0719-532X</p> <p><strong>p-ISSN</strong> 0719-3904</p> https://revistas.uautonoma.cl/index.php/ijmss/article/view/1355 Morphological and biochemical effects of carnosic acid on human hepatocellular carcinoma HepG2 cells 2020-12-29T23:32:04+00:00 Askin Keskin Kaplan askinkkaplan@gmail.com Hatice MARAS haticemaras@maltepe.edu.tr Merve Kolsan kolsandilara@hotmail.com Mustafa Sitar merincsitar@maltepe.edu.tr Ranan Gülhan Aktaş ranan.aktas@maltepe.edu.tr <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Antecedentes / objetivo</span></span></span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> : La muerte celular autofágica y la apoptosis de células tumorales se ha convertido en uno de los principales objetivos en el tratamiento del cáncer, mientras que las líneas celulares tumorales se utilizan principalmente en estudios para proporcionar datos importantes para la evaluación de posibles sustancias anticancerígenas. </span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">En este estudio, nuestro objetivo fue evaluar los cambios morfológicos y bioquímicos, incluida la tasa de apoptosis y los niveles de alfa fetoproteína (AFP) a diferentes concentraciones de ácido carnósico (CA) en células de carcinoma hepatocelular humano HepG2. </span></span></span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Materiales y métodos</span></span></span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> : Carcinoma hepatocelular humano (células HepG2 de séptimo pase). Las líneas celulares se cultivaron en cubreobjetos de vidrio Schott D263M de 11 µM colocados en placas de 12 pocillos y se trataron con DMSO, concentraciones de CA 1, 2,5, 5 y 10 µM durante 24 horas. </span><span style="vertical-align: inherit;">48 y 72 horas. </span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Los datos morfológicos y bioquímicos se registraron diariamente, incluidas las tasas de apoptosis demostradas por Caspasa 3, las expresiones de Anexina V bajo luz invertida y microscopía de inmunofluorescencia, luego se analizaron los datos para determinar la significación estadística. </span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Los niveles de AFP, albúmina y ganancias totales se analizaron espectrofotométricamente para evaluación bioquímica. </span></span></span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Resultados</span></span></span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> : Nuestros resultados muestran que CA inhibió significativamente la proliferación de células HepG2 de una manera dependiente de la dosis y el tiempo y causó significativamente la formación de vacuolas autofágicas comenzando desde 5 µM y alcanzando significancia a concentraciones de 10 µM. </span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Se produce una disminución significativa en la AFP cuando se examinan las expresiones de 48 y 72 horas, alcanzando el nivel más bajo a las 72 horas en el grupo de CA 10 µM. </span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Además, el aumento en los niveles de albúmina alcanzó la significación solo en el grupo de 48 h, mientras que también se observaron aumentos no significativos en los grupos de 24 hy 72 h. </span></span></span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Conclusión:</span></span></span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Nuestro estudio actual demuestra un aumento significativo en las tasas de apoptosis por el ácido carnósico principalmente a concentraciones de 10 µM, lo que respalda su efecto anticancerígeno en las células HepG2. </span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Estos hallazgos también están respaldados por cambios en los análisis bioquímicos de los niveles de albúmina y AFP a concentraciones de 10 µM.</span></span></span></span></p> <p> </p> 2021-01-11T00:00:00+00:00 Copyright (c) 2021 Askin Kaplan, Hatice Maras, Merve Dilara Kolsan , Mustafa Erinç Sitar, Ranan Gülhan Aktaş https://revistas.uautonoma.cl/index.php/ijmss/article/view/1472 Characterization of anatomical structures of the larynx by ultrasonography 2021-03-03T12:05:06+00:00 Carlos Mena Canata cmena@med.una.py Ashiria Reseda Acuña Ramírez ashiria1995@gmail.com Gustavo Melgarejo gusmel_92@outlook.com Rodrigo Cáceres rodrigomcaceres@gmail.com Raúl Tornaco raultornaco@gmail.com <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">La laringe es un órgano extraño ubicado en la línea media del cuello, compuesto por cartílago, músculos y ligamentos. </span><span style="vertical-align: inherit;">La TC y la RM se realizan como técnicas de imagen de primera elección en el estudio de laringe; </span><span style="vertical-align: inherit;">sin embargo, no están exentos de limitaciones. </span><span style="vertical-align: inherit;">La ecografía es un método accesible de alta resolución con una visualización relativamente buena de las diferentes estructuras de la laringe. </span><span style="vertical-align: inherit;">El objetivo del trabajo fue determinar las características de estructuras anatómicas laríngeas identificables ecográficamente.</span></span></p> <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">En este trabajo observacional descriptivo, transversal, prospectivo, se estudiaron 20 pacientes, sin patología laríngea, con edades comprendidas entre los 20 y los 35 años, ambos sexos. </span><span style="vertical-align: inherit;">La ecografía laríngea se realizó con un transductor de ultrasonido Phillips® con sonda lineal de 4 a 12 MHz, partes blandas preestablecidas</span></span></p> <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">En todos los casos se pudieron identificar y medir cartílago tiroides, cricoides y epiglotis, y en un gran porcentaje de estos las cuerdas vocales, bandas ventriculares y esquina anterior. </span><span style="vertical-align: inherit;">El cartílago aritenoide solo fue visible en el 85% de los casos.</span></span></p> <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">La ecografía se presenta como un método auxiliar útil en el estudio de la anatomía de la laringe, proponiendo el seguimiento y realización de nuevos estudios que puedan complementar este estudio y su validez.</span></span></p> 2021-04-06T00:00:00+00:00 Copyright (c) 2021 Prof. Dr. Carlos Mena Canata, Dra. Ashiria Reseda Acuña Ramírez , Dr. Gustavo Melgarejo, Dr. Rodrigo Cáceres, Dr. Raúl Tornaco https://revistas.uautonoma.cl/index.php/ijmss/article/view/1443 Relationship between cardiovascular parameters and body mass index in perimenopausal women 2021-01-31T22:20:05+00:00 Anxela Soto-Rodríguez anxela.soto.rodriguez@sergas.es Raquel Leirós-Rodríguez rleiros@uvigo.es Jose Luis García-Soidán jlsoidan@uvigo.es Jesús García-Liñeira jesgarcia@alumnos.uvigo.es <p><strong>Introduction</strong>: Cardiovascular disease (CVD) is the most common cause of death in women worldwide. Estrogen deficiency due to menopause is associated with an increased risk of this pathology.<br /><strong>Objective</strong>: To analyze cardiovascular risk factors in perimenopausal women with at least one major modifiable cardiovascular risk factor (diabetes, hypertension, dyslipemia) between the ages of 45 and 60 of two urban primary care services.<br />Methodology: Cross-sectional descriptive study in two health centers in the city of Ourense (Novoa Santos Health Center and A Ponte Health Center). The variables analyzed were: estrogenic activity, pharmacological treatment, smoking habit, quality of life, body mass index (BMI), total cholesterol, high density lipoprotein (cHDL), low-density lipoprotein (cLDL) and triglycerides, systolic blood pressure (TAS), diastolic blood pressure (TAD), heart rate (FC). The study was approved by the Ethics Committee of Galicia. Data analysis was performed through the free R software.<br /><strong>Results</strong>: 316 women participated, of whom 64.9% were menopausal. The average age of the sample was 53.35 ± 4.35 years. The average BMI value was 28,125 ± 5.54 Kg/m2. 27.8% said they had a smoking habit. 77.2% of the women in the sample had total cholesterol levels ≥200 mg/dL. In relation to the cLDL, in 72.6% of the population studied it was ≥130 mg/dL. A statistically significant correlation was observed between BMI and triglyceride, cHDL, TAS, TAD and FC levels.<br /><strong>Conclusion</strong>: Perimenopausal women had a high prevalence of smoking habit, obesity and overweight, despite suffering at least one cardiovascular risk factor. On the other hand they showed a low quality of life in both the physical and mental dimension</p> 2021-02-17T00:00:00+00:00 Copyright (c) 2021 Anxela Soto-Rodríguez, Raquel Leirós-Rodríguez , Jose Luis García-Soidán , Jesús García-Liñeira https://revistas.uautonoma.cl/index.php/ijmss/article/view/1423 Intrahospitalary location and antimicrobial initial treatment in patients with acquired pneumonia in the community and their relationship with the frequency and quality of the stratification process 2021-01-21T19:25:46+00:00 Luis Corona Martínez luis.corona@gal.sld.cu Iris González Morales iris.gonzalez@gal.sld.cu María Caridad Fragoso Marchante dayanadariel95@yahoo.com <p>The initial evaluation of the patient's condition with pneumonia is a very important assistance action. The objective was evaluate the relationship between the frequency and quality of the stratification process of the patient with pneumonia, and the execution of suggestions of intrahospitalary location and the initial antimicrobial treatment of stratification instrument. A descriptive study was done on a population of 1,809 patients hospitalized during 10 years. The indexes of intrahospitalary location and of antimicrobian initial treatment were analized according to the suggestions of the instrument; in the statistical analysis it was used the odds ratio and the statistician X<sup>2</sup>, with a significant level of 95%. The intrahospitalary location was in agreement with the suggestion of the instrument in 96% of the cases, with the lowest value in patients with serious pneumonia and high recovery probabilities (82%, p &lt;,05). The frequency of intrahospitalary location was bigger and veryfied with the suggestion of the instrument in the termed well stratified patients (p &lt;,05), fundamentally in the patients with serious pneumonia and high recovery probabilities. The correspondence of the initial antimicrobial treatment with the proposal of the instrument was of 61%; the stratum IIIA showed the highest value (80%, p &lt;,05). As conclusions<strong>,</strong> a high performance in the execution of the suggestion of the intrahospitalary location has been one of the characteristics of the process, although as a negative element it stands out the frequent non-fulfillment of the suggestion of the initial antimicrobial treatment. There was a relationship between the stratification process and the execution of the suggestion of the intrahospitalary location.</p> 2021-02-18T00:00:00+00:00 Copyright (c) 2021 Luis Alberto Corona Martínez , Iris González Morales, María Caridad Fragoso Marchante https://revistas.uautonoma.cl/index.php/ijmss/article/view/1358 Evaluation Of The Radiofrequency Ablation Of Lumbar Sympathetic Ganglia In Lower Limb Ischemic Ulcers In Indian Population 2021-01-08T13:55:24+00:00 Rajat Singh dr.rajatsingh4853@gmail.com Rajendra Kulkarni drrmk@rediffmail.com Kalpana Kulkarni drrmk@rediffmail.com Karthik Chavannavar karthikchavannavar3806@gmail.com <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Antecedentes:</span></span></span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> la</span></span></span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> simpatectomía lumbar mediante radioablación es un tratamiento útil de la isquemia periférica. </span><span style="vertical-align: inherit;">Sin embargo, la eficacia clínica con respecto a las úlceras de las extremidades inferiores no está suficientemente establecida en la población india. </span><span style="vertical-align: inherit;">El estudio se realizó para evaluar el papel de la ablación por radiofrecuencia (ARF) de los ganglios simpáticos lumbares en la cicatrización de las úlceras isquémicas del miembro inferior. </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Método:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> El estudio prospectivo con 63 pacientes registrados en el servicio de Cirugía General con úlceras isquémicas de miembros inferiores entre diciembre de 2017 y julio de 2019 fueron tratados con ARF. </span><span style="vertical-align: inherit;">Se excluyó del estudio a los pacientes con enfermedad cardiopulmonar, embarazadas, malformaciones congénitas o infección cutánea en el lugar de la intervención, o que padecían trastornos hemorrágicos. </span><span style="vertical-align: inherit;">Se realizó una investigación clínica de la herida y se recopilaron datos demográficos. </span><span style="vertical-align: inherit;">La reducción comparativa en el tamaño de la herida se evaluó mediante el ANOVA de Friedman (P &lt;0,001). </span><span style="vertical-align: inherit;">La diferencia en la puntuación del dolor, la estancia hospitalaria y la distancia recorrida se evaluaron mediante la prueba de pares emparejados de Wilcoxon (P &lt;0,001), la prueba t para datos no emparejados y la prueba t para datos emparejados (P &lt;0,05). </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Resultado: la</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> mayoría de los pacientes eran hombres (n = 40) con una edad media de 60,93 DE14,34 años. </span><span style="vertical-align: inherit;">Se observó una reducción significativa en el tamaño de la herida, las puntuaciones de dolor y la estancia hospitalaria después del procedimiento (P &lt;0,001). </span><span style="vertical-align: inherit;">El número de sesiones de RFA se asoció significativamente con el tamaño de la úlcera y la clasificación de Fontaine 2 y 3 (P &lt;0,0001). </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Conclusión: La</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> ARF de los ganglios simpáticos lumbares es una posible modalidad de tratamiento para las úlceras isquémicas de las extremidades inferiores.</span></span></p> 2021-01-26T00:00:00+00:00 Copyright (c) 2021 Rajat K Singh, Rajendra M kulkarni, Kalpana R Kulkarni , Karthik Chavannavar https://revistas.uautonoma.cl/index.php/ijmss/article/view/1482 Applicability of the Tanaka-Johnston method for the estimation of the mesiodistal diameter of canines and premolars in patients of 12-18 years old 2021-03-03T12:02:45+00:00 Laura Pereda Vázquez lauraperedavazquez@gmail.com Oscar Ameneiros Narciandi oscaran@infomed.sld.cu Aracelys Soto Rico aracelys881126@gmail.com <p>The Tanaka-Johnston method is used worldwide to predict the diameter of canines and premolars not erupted for the convenience of not needing boards or x-rays for use. However, in recent years researchers from several countries have shown that when used in a different population for which it was designed, it can overestimate or underestimate the values. In Cuba, where the facial pattern of the population differs from the ideal for this method, it has been highly used, but there are very few studies where the reliability or accuracy of the predictions of the same is validated. Therefore, the objective of this research is to determine the applicability of the Tanaka-Johnston method for estimating the mesiodistal diameter of canines and premolars in patients aged 12-18 years. A descriptive and cross-cutting study was conducted from June 2019 to January 2020 with a population of 140 patients of both sexes between 12 and 18 years of age from Cuba. Measurements were made of the mesiodistal widths of the lower incisors, all canines, and premolars. Frequency distributions were made to the variables studied and the results were presented in statistical tables. The <em>t-Student</em> statistical test was used to verify significant differences. The main results obtained were that the Tanaka-Johnston method tends to overestimate the values for the female sex and underestimate them for the male, both between 0.2 and 0.3 mm, but this difference is not significant. It is concluded that the Tanaka-Johnston method can be applied in the population studied for the prediction of the mesiodistal width of unerupted canines and premolars.</p> 2021-03-26T00:00:00+00:00 Copyright (c) 2021 Dra. Laura Pereda Vázquez, Dr.Oscar Ameneiros Narciandi, Dra. Aracelys Soto Rico https://revistas.uautonoma.cl/index.php/ijmss/article/view/1347 Differentiated thyroid cancer clinical trends in Quito, Ecuador 2021-01-05T23:41:24+00:00 Luis Pacheco-Ojeda luispacheco.o@hotmail.com Ana Martínez-Jaramillo anluma@hotmail.com Hugo Romo-Castillo hromo56@gmail.com Mario Montalvo-Burbano drmariomontalvo@gmail.com <p><strong>Introduction. </strong> Thyroid cancer is currently the first most common cancer in women in Ecuador. This study aimed to assess the changes in clinical presentation and diagnosis of differentiated thyroid cancer at a third level hospital in Quito, Ecuador.</p> <p><strong>Methods and Materials. </strong> The study was a retrospective case series performed in three consecutive periods from 1990 to 2019 at a tertiary level hospital, Quito Ecuador, where the clinical records of 875 patients who had been diagnosed and surgically treated for differentiated thyroid cancer were retrospectively reviewed. Demographic, clinical, imaging, and pathological data were collected and analyzed.</p> <p><strong>Results</strong>. Significant trends toward older age, higher educational level, less palpable primary tumors, less palpable neck nodes, less DM, more ultrasound, CT and cytology exams, smaller primary tumors, more stage I patients, and more histological variant description, were found.</p> <p><strong>Conclusion. </strong>The thyroid cancer incidence in Ecuador has not only steadily increased but also the clinical presentation, diagnostic and therapeutic approaches have significantly changed over the last three decades.</p> <p><strong> </strong></p> 2021-02-18T00:00:00+00:00 Copyright (c) 2021 Luis Pacheco-Ojeda , Ana Martínez-Jaramillo, Hugo Romo-Castillo , Mario Montalvo-Burbano https://revistas.uautonoma.cl/index.php/ijmss/article/view/1450 Echocardiographic prognostication of new onset heart failure in a cohort of ischemic heart disease patients 2021-02-07T14:55:37+00:00 Senbeta Abdissa drsenbetag@yahoo.com <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Antecedentes Los</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> predictores ecocardiográficos de insuficiencia cardíaca de nueva aparición en pacientes con cardiopatía isquémica con fracción de eyección ventricular izquierda reducida (HFrEF) o con fracción de eyección ventricular izquierda conservada (HFpEF) en etíopes y africanos subsaharianos no son bien conocidos. </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Métodos</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Se reclutaron y siguieron retrospectivamente doscientos veintiocho pacientes con cardiopatía isquémica. </span><span style="vertical-align: inherit;">Se realizó un análisis de las características clínicas y ecocardiográficas basales de los pacientes y de los factores de riesgo de IC-FEc de nueva aparición y de IC-FEr de nueva aparición. </span><span style="vertical-align: inherit;">Los criterios de exclusión fueron insuficiencia cardíaca conocida al inicio del estudio y aquellos que no tenían datos de ecocardiografía.</span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Resultados. </span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Durante el período de seguimiento, se desarrolló insuficiencia cardíaca en el 62,2% (61/98) de los pacientes con cardiopatía isquémica con fracción de eyección ventricular izquierda conservada y en el 70,1% (92/130) de los pacientes con cardiopatía isquémica con fracción de eyección ventricular izquierda reducida. </span><span style="vertical-align: inherit;">No encontramos diferencias significativas entre HFrEF y HFpEF en el tiempo hasta la nueva aparición de insuficiencia cardíaca. </span><span style="vertical-align: inherit;">La presión arterial sistólica, la presión arterial diastólica, la diabetes, la aurícula izquierda y la dimensión diastólica del ventrículo izquierdo tuvieron una asociación significativa con la HFrEF de nueva aparición en el análisis de regresión univariante. </span><span style="vertical-align: inherit;">Mientras que la HFpEF de nueva aparición se asoció significativamente con la edad, el sexo, la presencia de hipertensión, la presión arterial sistólica y la dimensión diastólica del ventrículo izquierdo. </span><span style="vertical-align: inherit;">En el análisis de regresión de Cox, la dimensión diastólica del ventrículo izquierdo se asoció tanto con HFpEF de nueva aparición como con HFrEF. </span><span style="vertical-align: inherit;">Edad, diabetes. </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Conclusión.</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Este estudio de cohorte en pacientes con cardiopatía isquémica sugiere un papel clave para la dimensión diastólica del ventrículo izquierdo, el tamaño de la aurícula izquierda, la diabetes, el sexo y la edad como predictores de IC-FEr e IC-FEc de nueva aparición. </span><span style="vertical-align: inherit;">Las estrategias dirigidas a la prevención y el tratamiento temprano de la diabetes, la dilatación del ventrículo izquierdo y la aurícula izquierda pueden prevenir una proporción considerable de HFrEF o HFpEF.</span></span></p> 2021-02-17T00:00:00+00:00 Copyright (c) 2021 Senbeta Abdissa https://revistas.uautonoma.cl/index.php/ijmss/article/view/1439 Clinical phenotypes of chronic obstructive pulmonary disease in patients treated at the Hospital Neumológico de La Habana. 2021-01-30T22:38:26+00:00 Ilis Herrera-Monterrey ilis.herrera@nauta.cu Donel González Díaz dmachual@gmail.com Otilia María Terry-Valles donelglez@infomed.sld.cu Drialis Díaz-Garrido drialisdg@gmail.com Sergio Fernández-García fernandez.sergito1976@gmail.com <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Introducción:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> La identificación de fenotipos clínicos es clave en la modulación de la expresión clínica, para un tratamiento integrado de la EPOC. </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Objetivos:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Caracterizar los fenotipos clínicos de la EPOC en pacientes atendidos en el Hospital Neumológico Benéfico Jurídico. </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Métodos:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Se realizó un estudio observacional descriptivo retrospectivo en 172 pacientes con diagnóstico de EPOC en el Hospital Neumológico Benéfico Jurídico en 2017. </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Resultados:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">El 38,4% de los pacientes tenían entre 70 y 79 años. </span><span style="vertical-align: inherit;">Del total de pacientes, el 54,6% eran varones. </span><span style="vertical-align: inherit;">El 52,9% eran fumadores activos y el 41,3% exfumadores. </span><span style="vertical-align: inherit;">Aunque las diferencias no fueron significativas, la edad avanzada y el sexo masculino fueron más frecuentes en el fenotipo agudizador enfisematoso y agudizador bronquial crónico. </span><span style="vertical-align: inherit;">El tabaquismo activo fue más frecuente en el fenotipo enfisematoso exacerbante. </span><span style="vertical-align: inherit;">Todos los pacientes con el fenotipo de exacerbador bronquial crónico tuvieron dos o más exacerbaciones, mientras que la exacerbación enfisematosa se asoció con una gravedad grave de la EPOC (46,7%). </span></span><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Conclusiones:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">El sexo masculino y la edad avanzada muestran una tendencia a relacionarse con el fenotipo enfisematoso agudizante y agudizador de la bronquitis crónica, mientras que el tabaquismo activo es más frecuente en el fenotipo enfisematoso agudizante. </span><span style="vertical-align: inherit;">El fenotipo agudizador de bronquitis crónica se relaciona con mayores exacerbaciones y exacerbaciones enfisematosas con mayor gravedad de la EPOC.</span></span></p> <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">.</span></span></span></span></p> 2021-02-17T00:00:00+00:00 Copyright (c) 2021 Ilis Herrera-Monterrey, Donel González-Díaz, Otilia María Terry-Valles, Drialis Díaz-Garrido, Sergio Fernández-García https://revistas.uautonoma.cl/index.php/ijmss/article/view/632 Evaluation of the prescription of oral hypoglycemic agents in the adult population with type 2 diabetes mellitus 2020-11-23T18:19:21+00:00 Daimy Casanova Moreno mcasanovamoreno@nauta.cu Maria de la Caridad Casanova Moreno mcasanovamoreno@nauta.cu Ismary Acosta Martìnez ismari@infomed.sld.cu Jessica María González Casanova jessm@nauta.cu Francisco Machado Reyes francisco@infomed.sld.cu <p>Errors in the prescription of drug treatment for type 2 diabetes are detected at the primary level of care. the purpose of this study was to evaluate the quality of the prescription of oral hypoglycemic agents in patients attended in the family doctor's offices of the Hermanos Cruz University Polyclinic, Pinar del Río distrit, Cuba. A descriptive and cross-sectional study of the use of medications was carried out, classified within these as indication-prescription with elements of the therapeutic scheme and factors that condition prescription habits. The universe was made up of 1575 patients diagnosed with type 2 diabetes mellitus treated with oral hypoglycemic agents who belonged to the 20 family medical offices. The study sample was carried out by the non-probabilistic sampling method (for convenience) (n = 846). The information was obtained from the clinical history and control card of the patients to acquire these medications. The age of 40-49 years, the female sex and between 5-10 years of evolution of the disease predominated. The first line of treatment was not used in 43.6% of the cases; no case had laboratory studies for the use of Metformin. The prescription and dose was adequate, but not its rational use. The most frequent interactions were pharmacokinetic ones. The rational use of oral hypoglycemic agents was deficient, which makes it necessary to expand the dissemination of a treatment protocol to improve the use of these drugs at the primary level of care.</p> 2021-01-09T00:00:00+00:00 Copyright (c) 2021 Daimi Casanova Moreno, Dra. María Casanova Moreno, Ismary Acosta Martínez, Dra. Jessica González Casanova, Francisco Machado Reyes https://revistas.uautonoma.cl/index.php/ijmss/article/view/1369 Order and chronology of temporary teeth breaking 2021-01-10T15:01:59+00:00 Leslie Imara de Armas Gallegos leslieimara@infomed.sld.cu Nurys Mercedes Batista González nurysbatista@infomed.cu Eliane Fernández Pérez elaine@infomed.sld.cu <p>The order and chronology of the temporary tooth eruption is an expression of the child's growth and influences his later dental development. Having knowledge about the average age of emergence of each tooth is useful to establish a diagnosis, prevention and treatment of malocclusions, for which the objective of this research is to characterize the pattern of emergence of primary dentition in children in Cerro district, Havana, Cuba. For this, a descriptive observational study was designed in 370 children of both sexes between 0 and 36 months of age, in said clinic during September / 2017 to January / 2020. The variables were studied: age, sex, tooth, hemiarcade and chronology of the dental outbreak. Frequency distributions were made to all the variables under study and the results are presented in statistical tables. The t-Student test was used to verify significant differences. The main results obtained were that the teeth of the maxillary arch erupted before those of the mandibular, except for the central incisors and the lower left lateral incisor. Although the fact that the dental flare began first in males in both arches (5,86 months in the maxilla, ± 0,92; and in the mandible 4,92 months ± 1,09), the time period of outbreak was somewhat faster in females (19,83 months in the maxilla and 21,64 months in the mandible) and males (20,26 months and 22,16 months), but without significant differences (p &lt;0, 05). It is concluded that the eruption pattern was similar to that described in the literature, except for slight advancement for the central incisors and delay in second primary molars.</p> 2021-01-21T00:00:00+00:00 Copyright (c) 2021 Dra. Leslie Imara de Armas Gallegos, Dra. Nurys Mercedes Batista González, Dra. Elaine Fernández Pérez https://revistas.uautonoma.cl/index.php/ijmss/article/view/682 Unusual Clinical Manifestation of Epidermoid Cyst Mimicking Basal Cell Carcinoma 2020-12-21T17:48:13+00:00 Khairuddin Djawad duddin@ymail.com <p>Epidermoid cyst is a type of cutaneous cyst commonly found in daily practice. The facial area is the most common area for emergence of this benign condition. Simple extirpation is usually performed to remove epidermoid cysts. However, in rare cases, epidermoid cysts can evolve into malignancies such as basal cell carcinoma (BCC) or can mimic them, which adds difficulty when making a proper diagnosis. In cases of doubt, histopathology plays a key role in aiding diagnosis. This case report is about a 33-year-old woman with suspected nodular lesion that mimicked BCC, but after histopathological analysis was confirmed to be epidermoid cyst.</p> 2021-01-11T00:00:00+00:00 Copyright (c) 2021 Dr. Khairuddin Djawad https://revistas.uautonoma.cl/index.php/ijmss/article/view/666 Chronic subdural hematoma 2020-12-07T15:28:58+00:00 Blanca Caridad Piedra Herrera bcpiedra.mtz@infomed.sld.cu Yanet Acosta Piedra yanetacosta69@nauta.cu <p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">El hematoma subdural crónico (HAC) es una patología neuroquirúrgica frecuente que se reconoce como consecuencia de traumatismos craneoencefálicos leves que suelen diagnosticarse en pacientes seniles, aunque puede presentarse en pacientes jóvenes sin antecedentes de traumatismo. </span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">El objetivo de este trabajo es la presentación de un paciente con HAC bilateral, de características inusuales. </span></span><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Caso clínico: se presenta una paciente de sexo femenino de 46 años sin antecedentes de traumatismo craneoencefálico u otra patología concomitante, que consultó por cefalea de 15 días. </span><span style="vertical-align: inherit;">La exploración física confirmó midriasis, pupila de Hutchinson, papiledema bilateral y exoforia del ojo derecho, parálisis del tercer par craneal y ataxia del tronco. </span><span style="vertical-align: inherit;">Fue catalogada con Glasgow 13. Se realizó tratamiento precoz contra el edema cerebral y las manifestaciones desaparecieron en gran parte. </span><span style="vertical-align: inherit;">Una tomografía computarizada diagnosticó un hematoma subdural fronto temporal bilateral con desplazamiento de las estructuras de la línea media hacia la izquierda. </span><span style="vertical-align: inherit;">Fue intervenida de urgencia y fue dada de alta completamente recuperada tres días después. </span><span style="vertical-align: inherit;">Conclusión: Las HSC pueden presentarse con diferentes formas clínicas, simulando procesos tumorales expansivos, ataques cerebrovasculares, demencias o entidades neurológicas de otra naturaleza. </span><span style="vertical-align: inherit;">El manejo de casos por parte de médicos y neurocirujanos fue rápido y efectivo, lo que explica que el paciente tuvo una recuperación temprana y completa. </span><span style="vertical-align: inherit;">En estos casos, la acción médica es decisiva para el éxito del tratamiento.</span></span></p> <p> </p> 2021-01-09T00:00:00+00:00 Copyright (c) 2021 Dra. Blanca Piedra Herrera, Dra. Yanet Acosta Piedra https://revistas.uautonoma.cl/index.php/ijmss/article/view/673 Surviving Complications of Retroperitoneal Fibrosis with Intermittent Relapses over a Period of 20 years: Case report and literature Review 2020-12-14T18:39:18+00:00 Sunita Dinkar dinkarsunita843@gmail.com Srajan Dashore srajan.dashore@gmail.com Sunil Joshi dr_sunil_joshi@yahoo.com Himanshu Shah doctorhimanshushah@yahoo.com Tushar Shah tusharnalini@gmail.com <p>Idiopathic retroperitoneal fibrosis is a rare fibro-inflammatory disease of varied etiology which usually originates around aorta and spreads caudally along Iliac vessels into adjacent<br />retroperitoneum causing ureteral obstruction as the most frequent complication.<br />A 53-year-old male patient presented with complaint of mild pain in both the legs off and on. On investigating further, we found that he had been struggling with intermittent relapses every 3-4 years for last 20 years since he was first diagnosed with Idiopathic Retroperitoneal Fibrosis. He was<br />33-year-old when he first developed the symptoms of anuria for 48 hours and was diagnosed with Idiopathic retroperitoneal fibrosis. This was followed by atrophy of left kidney and hypertension 6 years later, then hypothyroidism after another 3years and finally involvement of Inferior Vena<br />Cava and acute Deep Vein Thrombosis of lower limbs after another 3-4 years. His deep vein thrombosis was well managed in time. He was put on glucocorticoids everytime he had a relapse and a complication.<br />We did a review of literature to understand recent advances about its pathogenesis, diagnosis, investigations and management. We searched in PubMed using terms like retroperitoneal fibrosis<br />alone and in combination with related terms such as Inferior Vena Cava thrombosis, Deep Vein Thrombosis, Tamoxifen, Methotrexate. This case is unique as it is very rare to find acute Deep Vein Thrombosis in Idiopathic retroperitoneal fibrosis without development of any collaterals<br />when Inferior Vena Cava lumen is compromised to almost complete obstruction. After a follow up of 20 years patient is doing well in terms of physical activity and psychological<br />wellbeing with anti-hypertensives, thyroxine and anti-coagulants. Is the disease-free interval actually free of the disease or it just subsided with immunosuppressants to become active after some time?</p> 2021-01-09T00:00:00+00:00 Copyright (c) 2021 Dr. Sunita Dinkar, Dr. Srajan Dashore, Dr. Sunil Joshi, Dr. Himanshu Shah, Dr. Tushar Shah https://revistas.uautonoma.cl/index.php/ijmss/article/view/1503 Ramadan Fasting and COVID-19 Testing: Lessons learnt from 2020 2021-03-18T06:12:15+00:00 Prakash Gondode drprakash777@gmail.com Gitesh Sawatkar drgitesh@aiimsnagpur.edu.in Fatema Kamal drfatema@aiimsnagpur.edu.in Amrusha Raipure dramrusha@aiimsnagpur.edu.in Sandeep Dabhekar sandyent@aiimsnagpur.edu.in <p>Doesn't apply</p> 2021-03-23T00:00:00+00:00 Copyright (c) 2021 Dr Prakash Gyandev Gondode, Dr Gitesh Sawatkar, Dr Fatema Kamal , Dr Amrusha Raipure, Dr Sandeep Dabhekar