International Journal of Medical and Surgical Sciences <p><strong>International Journal of Medical and Surgical Sciences</strong>, (IJMSS) is a serial and peer-review publication, ascribed by the Faculty of Health Sciences and administered by the Vice-Rector's Office for Research and Postgraduate Studies of the Universidad Autónoma de Chile. IJMSS has an international scope, is open access and uses a License Creative Commons of Recognition -Non-Commercial-without derivatives 4.0 International (CC BY-NC-ND 4.0). The contents are available in open access immediately after being published.</p> <p><strong>Objective</strong>: To publish original research papers within the medical and surgical sciences, on all basic scientific aspects of structure, chemistry, developmental biology, physiology and pathology of relevant tissues, microbiology, biomaterials, and behavioral sciences. In general, analytical studies are preferred to descriptive ones.</p> <p><strong>Vision</strong>: IJMSS seeks to be a space for academic discussion and multidisciplinary dialogue in the area of biomedical, medical and surgical sciences in all its aspects, which contributes to scientific communication between research peers and academics in the area.</p> <p><strong>Aimed to</strong> professionals and technicians in the field of medical and surgical sciences, health administration, and related specialties.</p> <p>The Journal Publishes in continuous publication schema (four issues per year), original articles, reviews, short communications and letters to the editor in English and Spanish. The IJMSS has <strong>no article processing charges (APC)</strong> or article submission charges for any of the editorial processes or publication.</p> <p><strong>e-ISSN</strong> 0719-532X</p> <p><strong>p-ISSN</strong> 0719-3904</p> Universidad Autónoma de Chile en-US International Journal of Medical and Surgical Sciences 0719-3904 <p><span lang="en" xml:lang="en"><span title="">The publication are distributed under the <a href="">Creative Commons Attribution-NonCommercial 4.0</a> International license (<a href="">CC BY-NC-ND 4.0</a>).</span></span><span lang="en" xml:lang="en"><span title=""> The rights of the works published in this journal are property of the author and they are free to distribute and disseminate the same sources as long as he correctly cites the font of publication and these acts are not for commercial purposes.</span></span></p> Chronic subdural hematoma <p>Chronic subdural hematoma (CSH) is a common neurosurgical pathology that is recognized as a consequence of minor head injuries that are usually diagnosed in senile patients, although it can occur in young patients without a history of trauma.</p> <p>The objective of this work is the presentation of a patient with a bilateral CSH, with unusual characteristics.</p> <p>Clinical case: a 46-year-old female patient with no history of head trauma or other concomitant pathology is presented, who consulted for a 15-day-old headache. Physical examination confirmed mydriasis, Hutchinson’s pupil, bilateral papilledema and exophoria of the right eye, third cranial nerve palsy, and trunk ataxia. She was cataloged with Glasgow 13. Early anti-cerebral edema treatment was performed and the manifestations largely disappeared. A computed tomography scan diagnosed a bilateral fronto temporal subdural hematoma with displacement of the midline structures to the left. She underwent emergency surgery and was discharged completely recovered three days later. Conclusion: HSC can present with different clinical forms, simulating expansive tumor processes, cerebrovascular attacks, dementias or neurological entities of another nature. The case management by clinicians and neurosurgeons was quick and effective, which explains that the patient had an early and complete recovery. In these cases, medical action is decisive in the success of the treatment.</p> <p> </p> Blanca Caridad Piedra Herrera Yanet Acosta Piedra Copyright (c) 2021 Dra. Blanca Piedra Herrera, Dra. Yanet Acosta Piedra 2021-01-09 2021-01-09 8 2 1 7 10.32457/ijmss.v8i2.666 Unusual Clinical Manifestation of Epidermoid Cyst Mimicking Basal Cell Carcinoma <p>Epidermoid cyst is a type of cutaneous cyst commonly found in daily practice. The facial area is the most common area for emergence of this benign condition. Simple extirpation is usually performed to remove epidermoid cysts. However, in rare cases, epidermoid cysts can evolve into malignancies such as basal cell carcinoma (BCC) or can mimic them, which adds difficulty when making a proper diagnosis. In cases of doubt, histopathology plays a key role in aiding diagnosis. This case report is about a 33-year-old woman with suspected nodular lesion that mimicked BCC, but after histopathological analysis was confirmed to be epidermoid cyst.</p> Khairuddin Djawad Copyright (c) 2021 Dr. Khairuddin Djawad 2021-01-11 2021-01-11 8 2 10.32457/ijmss.v8i2.682 Morphological and biochemical effects of carnosic acid on human hepatocellular carcinoma HepG2 cells <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Antecedentes / objetivo</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> : La muerte celular autofágica y la apoptosis de células tumorales se ha convertido en uno de los principales objetivos en el tratamiento del cáncer, mientras que las líneas celulares tumorales se utilizan principalmente en estudios para proporcionar datos importantes para la evaluación de posibles sustancias anticancerígenas. </span><span style="vertical-align: inherit;">En este estudio, nuestro objetivo fue evaluar los cambios morfológicos y bioquímicos, incluida la tasa de apoptosis y los niveles de alfa fetoproteína (AFP) a diferentes concentraciones de ácido carnósico (CA) en células de carcinoma hepatocelular humano HepG2.</span></span></p> <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Materiales y métodos</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> : Carcinoma hepatocelular humano (células HepG2 de séptimo pase) .Las líneas celulares se cultivaron en cubreobjetos de vidrio Schott D263M de 11 µM colocados en placas de 12 pocillos y se trataron con DMSO, concentraciones de CA 1, 2,5, 5 y 10 µM durante 24 horas. 48 y 72 horas. </span><span style="vertical-align: inherit;">Los datos morfológicos y bioquímicos se registraron diariamente, incluidas las tasas de apoptosis demostradas por Caspasa 3, las expresiones de Anexina V bajo luz invertida y microscopía de inmunofluorescencia, luego se analizaron los datos para determinar la significación estadística. </span><span style="vertical-align: inherit;">Los niveles de AFP, albúmina y proteínas totales se analizaron espectrofotométricamente para evaluación bioquímica. </span></span></p> <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Resultados</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> : Nuestros resultados mostraron que CA inhibió significativamente la proliferación de células HepG2 de una manera dependiente de la dosis y el tiempo y causó significativamente la formación de vacuolas autofágicas comenzando desde 5 µM y alcanzando significancia a concentraciones de 10 µM. </span><span style="vertical-align: inherit;">Se observó una disminución significativa en la AFP cuando se examinaron las expresiones de 48 y 72 horas, alcanzando el nivel más bajo a las 72 horas en el grupo de CA 10 µM. </span><span style="vertical-align: inherit;">Además, el aumento en los niveles de albúmina alcanzó significación solo en el grupo de 48 h, mientras que también se observaron aumentos no significativos en los grupos de 24 hy 72 h. </span></span></p> <p><strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Conclusión:</span></span></strong><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"> Nuestro estudio actual demuestra un aumento significativo en las tasas de apoptosis por el ácido carnósico principalmente a concentraciones de 10 µM, lo que respalda su efecto anticancerígeno en las células HepG2. </span><span style="vertical-align: inherit;">Estos hallazgos también están respaldados por cambios en los análisis bioquímicos de los niveles de albúmina y AFP a concentraciones de 10 µM.</span></span></p> <p> </p> Askin Keskin KAPLAN Hatice MARAS Merve Kolsan Mustafa Sitar Ranan Gülhan Aktaş Copyright (c) 2021 Askin Kaplan, Hatice Maras, Merve Dilara Kolsan , Mustafa Erinç Sitar, Ranan Gülhan Aktaş 2021-01-11 2021-01-11 8 2 10.32457/ijmss.v8i2.1355 Evaluation of the prescription of oral hypoglycemic agents in the adult population with type 2 diabetes mellitus <p>Errors in the prescription of drug treatment for type 2 diabetes are detected at the primary level of care. the purpose of this study was to evaluate the quality of the prescription of oral hypoglycemic agents in patients attended in the family doctor's offices of the Hermanos Cruz University Polyclinic, Pinar del Río distrit, Cuba. A descriptive and cross-sectional study of the use of medications was carried out, classified within these as indication-prescription with elements of the therapeutic scheme and factors that condition prescription habits. The universe was made up of 1575 patients diagnosed with type 2 diabetes mellitus treated with oral hypoglycemic agents who belonged to the 20 family medical offices. The study sample was carried out by the non-probabilistic sampling method (for convenience) (n = 846). The information was obtained from the clinical history and control card of the patients to acquire these medications. The age of 40-49 years, the female sex and between 5-10 years of evolution of the disease predominated. The first line of treatment was not used in 43.6% of the cases; no case had laboratory studies for the use of Metformin. The prescription and dose was adequate, but not its rational use. The most frequent interactions were pharmacokinetic ones.</p> <p>The rational use of oral hypoglycemic agents was deficient, which makes it necessary to expand the dissemination of a treatment protocol to improve the use of these drugs at the primary level of care.</p> Daimy Casanova Moreno Maria de la Caridad Casanova Moreno Ismary Acosta Martìnez Jessica María González Casanova Francisco Machado Reyes Copyright (c) 2021 Daimi Casanova Moreno, Dra. María Casanova Moreno, Ismary Acosta Martínez, Dra. Jessica González Casanova, Francisco Machado Reyes 2021-01-09 2021-01-09 8 2 1 14 10.32457/ijmss.v8i2.632 Order and chronology of temporary teeth breaking <p>The order and chronology of the temporary tooth eruption is an expression of the child's growth and influences his later dental development. Having knowledge about the average age of emergence of each tooth is useful to establish a diagnosis, prevention and treatment of malocclusions, for which the objective of this research is to characterize the pattern of emergence of primary dentition in children in Cerro district, Havana, Cuba. For this, a descriptive observational study was designed in 370 children of both sexes between 0 and 36 months of age, in said clinic during September / 2017 to January / 2020. The variables were studied: age, sex, tooth, hemiarcade and chronology of the dental outbreak. Frequency distributions were made to all the variables under study and the results are presented in statistical tables. The t-Student test was used to verify significant differences. The main results obtained were that the teeth of the maxillary arch erupted before those of the mandibular, except for the central incisors and the lower left lateral incisor. Although the fact that the dental flare began first in males in both arches (5,86 months in the maxilla, ± 0,92; and in the mandible 4,92 months ± 1,09), the time period of outbreak was somewhat faster in females (19,83 months in the maxilla and 21,64 months in the mandible) and males (20,26 months and 22,16 months), but without significant differences (p &lt;0, 05). It is concluded that the eruption pattern was similar to that described in the literature, except for slight advancement for the central incisors and delay in second primary molars.</p> Leslie Imara de Armas Gallegos Nurys Mercedes Batista González Eliane Fernández Pérez Copyright (c) 2021 Dra. Leslie Imara de Armas Gallegos, Dra. Nurys Mercedes Batista González, Dra. Elaine Fernández Pérez 2021-01-21 2021-01-21 8 2 1 10 10.32457/ijmss.v8i2.1369 Surviving Complications of Retroperitoneal Fibrosis with Intermittent Relapses over a Period of 20 years: Case report and literature Review <p>Idiopathic retroperitoneal fibrosis is a rare fibro-inflammatory disease of varied etiology which usually originates around aorta and spreads caudally along Iliac vessels into adjacent<br />retroperitoneum causing ureteral obstruction as the most frequent complication.<br />A 53-year-old male patient presented with complaint of mild pain in both the legs off and on. On investigating further, we found that he had been struggling with intermittent relapses every 3-4 years for last 20 years since he was first diagnosed with Idiopathic Retroperitoneal Fibrosis. He was<br />33-year-old when he first developed the symptoms of anuria for 48 hours and was diagnosed with Idiopathic retroperitoneal fibrosis. This was followed by atrophy of left kidney and hypertension 6 years later, then hypothyroidism after another 3years and finally involvement of Inferior Vena<br />Cava and acute Deep Vein Thrombosis of lower limbs after another 3-4 years. His deep vein thrombosis was well managed in time. He was put on glucocorticoids everytime he had a relapse and a complication.<br />We did a review of literature to understand recent advances about its pathogenesis, diagnosis, investigations and management. We searched in PubMed using terms like retroperitoneal fibrosis<br />alone and in combination with related terms such as Inferior Vena Cava thrombosis, Deep Vein Thrombosis, Tamoxifen, Methotrexate. This case is unique as it is very rare to find acute Deep Vein Thrombosis in Idiopathic retroperitoneal fibrosis without development of any collaterals<br />when Inferior Vena Cava lumen is compromised to almost complete obstruction. After a follow up of 20 years patient is doing well in terms of physical activity and psychological<br />wellbeing with anti-hypertensives, thyroxine and anti-coagulants. Is the disease-free interval actually free of the disease or it just subsided with immunosuppressants to become active after some time?</p> Sunita Dinkar Srajan Dashore Sunil Joshi Himanshu Shah Tushar Shah Copyright (c) 2021 Dr. Sunita Dinkar, Dr. Srajan Dashore, Dr. Sunil Joshi, Dr. Himanshu Shah, Dr. Tushar Shah 2021-01-09 2021-01-09 8 2 1 18 10.32457/ijmss.v8i2.673