Biogenic amines as a diagnostic biomarker in inflammatory bowel diseases
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Abstract
Research has shown that polyamines obtained mainly from the diet and digestive tract bacterial source, involved in the development and maturation of intestinal epithelial tropism, both in animals and in infants. Such polyamines may play an important role in the physiology of inflammatory bowel diseases, besides being useful as potential diagnostic marked. Our objectives were to determine the values of biogenic amines in blood and in cultures of enteric bacteria in patients with inflammatory bowel diseases and study their effect on intestinal motility. To do this, we obtained samples of both blood and feces of 20 patients and 31 control cases to process and measure biogenic amines in the HPLC (High Performance Liquid Chromatography). We also did 12 preparations of isolated organs ileum and colon of mice to study intestinal motility. The results show both qualitative and quantitative differences of biogenic amines of blood cells, feces and / or source of enteric bacteria between the control group and intestinal diseases, with different correlations for Crohn's disease and ulcerative colitis, and between diagnostic markers. The conclusions suggest that the intestinal microbiota in these diseases seems to be different. Furthermore biogenic amines could modulate intestinal motility in both the ileum and colon.
References
Baumgart, D.C., y Sandborn, W.J. (2012). Crohn's disease. The Lancet, 3, 380(9853), 1590-1605.
Beaven, S.W., y Abreu, M.T. (2004). Biomarkers in inflammatory bowel disease. Current Opinion
in Gastroenterology, 20, 318-327.
Buts, J.P. (1998). Bioactive factors in milk. Archives de Pédiatrie, 5, 298-306. Consigny, Y., Modigliani, R., Colombel, J.F, Dupas, J.L., Lémann, M., y Mary, J.Y; Groupe d’Etudes Thérapeutiques des Affections Inflammatoires Digestives. (2006). A simple biological score for predicting low risk of short-term relapse in Crohn’s disease. Inflammatory Bowel Diseases, 12(7), 551-557.
García-Sánchez, V., Iglesias-Flores, E., González, R., et al. (2010). Does fecal calprotectin predict relapse in patients with Crohn’s disease and ulcerative colitis? Journal of Crohn´s and Colitis, 4(2), 144–152.
Gisbert, J.P., Gomollón, F., Maté, J., y Pajares, J.M. (2003). Papel de los anticuerpos anti-citoplasma
de los neutrófilos (ANCA) y antiSaccaromyces cerevisiae (ASCA) en la enfermedad inflamatoria intestinal. Gastroenterología y Hepatología, 26, 312-324.
Hou, J.K., Abraham, B., y El-Serag, H. (2011). Dietary intake and risk of developing inflammatory
bowel disease: a systematic review of the literature. American Journal of Gastroenterology, 106, 563-573.
Jones, D.T, Osterman, M.T, Bewtra, M., y Lewis, J.D. (2008). Passive smoking and inflammatory
bowel disease: a meta-analysis. American Journal of Gastroenterology, 103, 2382–2393.
Koelewijn, C.L, Schwartz, M.P, Samsom, M., et al. (2008). C-reactive protein levels during a relapse
of Crohn's disease are associated with the clinical course of the disease. World Journal of
Gastroenterology, 14, 85-89.
Jorquera, A.E. (2007). Definitions and classification of inflammatory bowel disease. Gastroenterología Latinoamericana, 18(2), 208-213.
Larqué, E., Sabater-Molina, M., y Zamora, S. (2007). Biological significance of dietary polyamines.
Nutrition, 23, 87-95.
Le Huërou-Luron, I., Blat, S., y Boudry, G. (2010). Breast-v. formula feeding: impacts on the
digestive tract and immediate and long-term health effects. Nutrition Research Reviews, 23(1), 23-26.
Lewis, J.D. (2011). The utility of biomarkers in the diagnosis and therapy of inflammatory bowel
disease. Gastroenterology, 140, 1817-1826, e2.
Schoepfer, A.M., Beglinger, C., Straumann, A., et al. (2010). Fecal calprotectin correlates more
closely with the Simple Endoscopic Score for Crohn’s disease (SES-CD) than CRP, blood
leukocytes, and the CDAI. American Journal of Gastroenterology, 105(1), 162-169.
Ter Steege, J.C, Buurman, W.A., y Forget, P.P. (1997). Spermine induces maturation of the
immature intestinal immune system in neonatal mice. Journal of Pediatric Gastroenterolology and Nutrition, 25(3), 332-340.
Vermiere, S., Van Assache, G., y Rutgeerts, P. (2005). C-reactive protein as an inflammatory marker in gastrointestinal diseases. Nature Clinical Practice Gastroenterology and Hepatology,
, 580-586.
Wallace, H.M., Fraser, A.V., y Hughes, A. (2003). A perspective of polyamine metabolism.
Biochemical Journal, 376(Pt 1), 1-14.
Yantiss, R.K., y Odze, R.D. (2006). Diagnostic difficulties in inflammatory bowel disease
pathology. Histopathology, 48, 116-132.