Mandibular Osteonecrosis Induced by Bisphosphonates in a Carrier of Chronicle Kidney Disease

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Published: Mar 1, 2017
DOI: https://doi.org/10.32457/ijmss.2017.005
Keywords:
Jaw osteonecrosis, Bisphosphonates, Chronic kidney disease

Article Details

How to Cite
da Silva, K., de Oliveira, G., Garbin-Júnior, E., Magro-Érnica, N., Griza, G., Conci, R., & Seguin, F. (2017). Mandibular Osteonecrosis Induced by Bisphosphonates in a Carrier of Chronicle Kidney Disease. International Journal of Medical and Surgical Sciences, 4(1), 1119–1125. https://doi.org/10.32457/ijmss.2017.005
Issue
Vol. 4 No. 1 (2017): March 2017
Section
Research Article

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Mandibular Osteonecrosis Induced by Bisphosphonates in a Carrier of Chronicle Kidney Disease

Main Article Content

Kaohana da Silva
Cirurgiã-Dentista, residente em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
Greison de Oliveira
Professor assistente do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
Eleonor Garbin-Júnior
Professor adjunto do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
Natasha Magro-Érnica
Professor adjunto do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
Geraldo Griza
Professor assistente do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUO.
Ricardo Conci
Professor assistente do curso de Residência em Cirurgia e Traumatologia Bucomaxilofacial da Universidade Estadual do Oeste do Paraná – UNIOESTE / Hospital Universitário do Oeste do Paraná – HUOP.
Fabiana Seguin
Professora assistente do curso de Odontologia da Universidade Estadual do Oeste do Paraná – UNIOESTE.

Abstract

The bisphosphonates are synthetic substances of inorganic pyrophosphate that have been the basis of treatment of patients with osteolytic diseases, such as multiple myeloma, malignant hypercalcemia, Paget's disease, or patients with bone metastases. Its main pharmacological effect is inhibition of bone resorption caused by osteoclasts, which have a reduced function. Their adverse effects are infrequent but include pyrexia, impaired renal function, hypocalcemia, and more recently, maxillo-mandibular ostenecrose induced bofosfonatos. In this report we describe a clinical case of jaw osteonecrosis induced by bisphosphonates in patient with chronic kidney disease and the treatment protocol performed.

References

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