Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review.

Article Sidebar

PDF
Published: Sep 1, 2017
DOI: https://doi.org/10.32457/ijmss.2017.020
Keywords:
platelet-rich plasma, platelet-rich fibrin, periodontal regeneration, periodontal surgery, periodontal defect, intrabony defect

Article Details

How to Cite
Cid, F. (2017). Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review. International Journal of Medical and Surgical Sciences, 4(3), 1196–1202. https://doi.org/10.32457/ijmss.2017.020
Issue
Vol. 4 No. 3 (2017): September 2017
Section
Research Article

The publication is free and its contents are distributed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND 4.0). The rights of the works published in this journal are property of the author and they are free to distribute and disseminate the same sources as long as he correctly cites the font of publication, these acts are not for commercial purposes and no derivative works are generated.

Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review.

Main Article Content

Felipe Cid
Cirujano Dentista, Universidad Autónoma de Chile, Sede Temuco.

Abstract

Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that allows fibrin membranes enriched with platelets and growth factors to be obtained after starting an anticoagulant-free blood collection without any biomechanical artificial modification. The objective of this review is to know the efficacy of platelet-rich plasma and platelet-rich fibrin in the periodontal regeneration of intrabony defects. The clinical implications for this autologous material are promising. Further long term, larger, multicentred randomized controlled clinical trials are required to determine the effects of PRP and PRF on the regeneration of alveolar bone due to periodontal disease.

References

Chandran, P. & Sivadas, A. Platelet-rich fibrin: Its role in periodontal regeneration., Saudi J. Oral. Dent. Res., 5(2), 117-122, 2014.

Chang, Y. C., Wu, K-C. & Zhao, J-H. Clinical application of platelet-rich fibrin as the sole grafting material in periodontal intrabony defects., J. Dent. Sci., 6:181-88, 2011.

Dori, F., Arweile, N., Huszar, T., Gera, I., Miron, R. J. & Sculean, A. Fiveyear results evaluating the effects of platelet-rich plasma on the healing of intrabony defects treated with enamel matrix derivative and natural bone mineral. J. Periodontol., 84(11):1546-55, 2013.

Hassan, K. S., Alagl, A. & Abdel-Hady, A. Torus mandibularis bone chips combined with platelet rich plasma gel for treatment of intrabony osseous defects: clinical and radiographic evaluation. Int. J. Oral Maxillofac. Surg., 41(12), 1519-1526, 2012.

Ozdemir, B. & Okte, E. Treatment of intrabony defects with beta-tricalciumphosphate alone and in combination with platelet-rich plasma. J. Biomed. Mater. Res. B. Appl. Biomater.., 100(4), 976-83,2012.

Pradeep, A. R., Rao, N. S., Agarwal, E., Bajaj, P., Kumari, M. & Naik, S. B. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J. Periodontol., 83(12):1499-507, 2012.

Pradeep, A.R., Bajaj, P., Rao, N. S., Agarwal, E. & Naik, S. B. Platelet-rich fibrin combined with a porous hydroxyapatite graft for the treatment of 3-wall intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J. Periodontol., 88(12)1288-96. 2017.

Roselló-Camps, À., Monje, A., Lin, G. H., Khoshkam, V., Chácez-Gatty, M., Wang, H. L., Gargallo-Albiol, J. & Hernandez-Alfaro, F. Plateletrich plasma for periodontal regeneration in the treatment of intrabony defects: a meta-analysis on prospective clinical trials. Oral Surg. Oral Med. OralPathol. Oral Radiol., 120(5), 562-74, 2015.

Shah, M., Patel, J., Dave, D. & Shah, S. Comparative evaluation of platelet-rich fibrin with demineralized freeze-dried bone allograft in periodontal infrabony defects: A randomized controlled clinical study. J. Indian. Soc. Periodontol., 19(1), 56-60, 2015

Sharma, A. & Pradeep, A. R. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J. Periodontol., 82(12):1705:12, 2011.

Sharma, A. & Pradeep, A. R. Autologous plateletrich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J. Periodontol., 82(10),1396-403, 2011.

Thorat, M., Pradeep, A. R. & Pallavi, B. Clinical effect of autologous platelet-rich fibrin in the treatment of intrabony defects: a controlled clinical trial. J. Clin. Periodontol., 38(10):925-32, 2011.

Yilmaz, S., Cakar, G., Ipci, S. D., Kuru, B. & Yildirim, B. Regenerative treatment with platelet-rich plasma combined with a bovinederived xenograft in smokers and non-smokers: 12-month clinical and radiographic results. J. Clin. Periodontol., 37(1), 80-87, 2010.

Yilmaz, S., Kabadayi, C., Ipci, S. D., Cakar, G. & Kuru, B. Treatment of intrabony periodontal defects with platelet-rich plasma versus plateletpoor plasma combined with a bovine-derived xenograft: a controlled clinical trial. J. Periodontol., 82(6), 837-44, 2011.