Biochemical parameters and dietary adherence in type 2 diabetics on hemodialysis

Biochemical parameters and dietary adherence in type 2 diabetics on hemodialysis

Main Article Content

Patricio Salazar Luna
Hazel Anderson Vásquez

Abstract

Introduction: Non-adherence to diet and fluid intake of the patient on hemodialysis can lead to the accumulation of toxic metabolites in the blood, resulting in increased morbidity and premature death. Objective: to determine biochemical parameters and diet adherence in patients with type 2 diabetes on hemodialysis attending the dialysis unit of the General Hospital IESS Riobamba.  Methods: A quantitative correlational, prospective, quasi-experimental, longitudinal design study was carried out in 87 subjects with diabetic nephropathy of both sexes between 40 and 70 years of age, who were receiving dialysis treatment. Biochemical measurements were taken (hematological, metabolic and lipid profile, albumin and electrolytes) and the questionnaire of non-adherence to diet and fluids for hemodialysis (DDFQ) was applied. Results: Significant differences were found (p<0.05) in the male gender in the following parameters: hemoglobin, creatinine and albumin. While in women significant differences were found in uric acid concentration. In both sexes significant differences were observed in phosphorus and potassium concentrations (p<0.05). About 80% of the patients manifested a degree of deviation from 1 to 3 (between no deviation and moderate deviation) to diet and fluid restrictions. Conclusion: most of the patients showed a good adherence to diet and liquid restrictions, which was related to the main biochemical parameters studied

References

Bakkal H., Dizdar OS., Erdem S., Kulakoğlu S., Akcakaya B., Katırcılar Y., & Uludag K. (2020). The Relationship Between Hand Grip Strength and Nutritional Status Determined by Malnutrition Inflammation Score and Biochemical Parameters in Hemodialysis Patients. J Ren Nutr, 30(6):548-555. https://doi: 10.1053/j.jrn.2020.01.026.

Beerendrakumar N., Ramamoorthy L., & Haridasan S. (2018). Dietary and Fluid Regime Adherence in Chronic Kidney Disease Patients. J Caring Sci, 7(1):17-20. https://doi: 10.15171/jcs.2018.003.

Cao M, Zheng S., Zhang W., & Hu G. (2023). Progress in the study of nutritional status and selenium in dialysis patients. Ann Med, 55(1):2197296. https://doi: 10.1080/07853890.2023.2197296.

Cui L., Zhang L., Li J., Li Y., Hao X., Xu Y., & Li C. (2024). Correlation between ultrafiltration rate and hemoglobin level and erythropoietin response in hemodialysis patients. Ren Fail, 46(1):2296609. https://doi: 10.1080/0886022X.2023.2296609.

Demir, S., Nawroth, P. P., Herzig, S., & Ekim Üstünel, B. (2021). Emerging Targets in Type 2 Diabetes and Diabetic Complications. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(18), e2100275. https://doi.org/10.1002/advs.202100275.

Efe, D., & Kocaöz, S. (2015). Adherence to diet and fluid restriction of individuals on hemodialysis treatment and affecting factors in Turkey. Japan journal of nursing science : JJNS, 12(2), 113–123. https://doi.org/10.1111/jjns.12055

Gama-Axelsson, T., Heimbürger, O., Stenvinkel, P., Bárány, P., Lindholm, B., & Qureshi, A. R. (2012). Serum albumin as predictor of nutritional status in patients with ESRD. Clinical journal of the American Society of Nephrology : CJASN, 7(9), 1446–1453. https://doi.org/10.2215/CJN.10251011

García Valderrama, F. W., Fajardo, C., Guevara, R., Gonzáles Pérez, V., & Hurtado, A. (2002). Mala adherencia a la dieta en hemodiálisis: papel de los síntomas ansiosos y depresivos [Poor adherence to diet in hemodialysis: role of anxiety and depression symptoms]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 22(3), 244–252.

Ghaderian, S. B., Hayati, F., Shayanpour, S., & Beladi Mousavi, S. S. (2015). Diabetes and end-stage renal disease; a review article on new concepts. Journal of renal injury prevention, 4(2), 28–33. https://doi.org/10.12861/jrip.2015.07

Gheith, O., Farouk, N., Nampoory, N., Halim, M. A., & Al-Otaibi, T. (2015). Diabetic kidney disease: world wide difference of prevalence and risk factors. Journal of nephropharmacology, 5(1), 49–56.

Hu, E. A., Coresh, J., Anderson, C. A. M., Appel, L. J., Grams, M. E., Crews, D. C., Mills, K. T., He, J., Scialla, J., Rahman, M., Navaneethan, S. D., Lash, J. P., Ricardo, A. C., Feldman, H. I., Weir, M. R., Shou, H., Rebholz, C. M., & CRIC Study Investigators (2021). Adherence to Healthy Dietary Patterns and Risk of CKD Progression and All-Cause Mortality: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation, 77(2), 235–244. https://doi.org/10.1053/j.ajkd.2020.04.019

Hu, Y., Liu, J., & Jin, H. (2023). Association between serum uric acid and phase angle in patients with type 2 diabetes mellitus: A cross-sectional study. Frontiers in endocrinology, 14, 1124565. https://doi.org/10.3389/fendo.2023.1124565

Iborra-Moltó, C., López-Roig, S., & Pastor-Mira, M.deL. (2012). Prevalence of adherence to fluid restriction in kidney patients in haemodialysis: objective indicator and perceived compliance. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 32(4), 477–485. https://doi.org/10.3265/Nefrologia.pre2012.Feb.11236

Ikizler, T. A., Cano, N. J., Franch, H., Fouque, D., Himmelfarb, J., Kalantar-Zadeh, K., Kuhlmann, M. K., Stenvinkel, P., TerWee, P., Teta, D., Wang, A. Y., Wanner, C., & International Society of Renal Nutrition and Metabolism (2013). Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney international, 84(6), 1096–1107. https://doi.org/10.1038/ki.2013.147

Kalantar-Zadeh, K., Streja, E., Kovesdy, C. P., Oreopoulos, A., Noori, N., Jing, J., Nissenson, A. R., Krishnan, M., Kopple, J. D., Mehrotra, R., & Anker, S. D. (2010). The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clinic proceedings, 85(11), 991–1001. https://doi.org/10.4065/mcp.2010.0336

Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2020). Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends. Journal of epidemiology and global health, 10(1), 107–111. https://doi.org/10.2991/jegh.k.191028.001

Khanna, D., Fitzgerald, J. D., Khanna, P. P., Bae, S., Singh, M. K., Neogi, T., Pillinger, M. H., Merill, J., Lee, S., Prakash, S., Kaldas, M., Gogia, M., Perez-Ruiz, F., Taylor, W., Lioté, F., Choi, H., Singh, J. A., Dalbeth, N., Kaplan, S., Niyyar, V., … American College of Rheumatology (2012). 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis care & research, 64(10), 1431–1446. https://doi.org/10.1002/acr.21772

Kovesdy, C. P., & Kalantar-Zadeh, K. (2012). Accuracy and limitations of the diagnosis of malnutrition in dialysis patients. Seminars in dialysis, 25(4), 423–427. https://doi.org/10.1111/j.1525-139X.2012.01097.x

Kugler, C., Vlaminck, H., Haverich, A., & Maes, B. (2005). Nonadherence with diet and fluid restrictions among adults having hemodialysis. Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing, 37(1), 25–29. https://doi.org/10.1111/j.1547-5069.2005.00009.x

Leggat J. E., Jr (2005). Adherence with dialysis: a focus on mortality risk. Seminars in dialysis, 18(2), 137–141. https://doi.org/10.1111/j.1525-139X.2005.18212.x

Li, X., Qureshi, A. R., Suliman, M. E., Heimburger, O., Barany, P., Stenvinkel, P., & Lindholm, B. (2023). Interleukin-6-to-Albumin Ratio as a Superior Predictor of Mortality in End-Stage Kidney Disease Patients. American journal of nephrology, 54(7-8), 268–274. https://doi.org/10.1159/000531191

Luo, D., Luo, Y., Zou, Y., Xu, Y., Fu, B., Yang, D., Yang, J., Xu, C., Ling, S., Li, S., & Qi, A. (2021). Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis. Lipids in health and disease, 20(1), 159. https://doi.org/10.1186/s12944-021-01546-1

Mikolasevic, I., Žutelija, M., Mavrinac, V., & Orlic, L. (2017). Dyslipidemia in patients with chronic kidney disease: etiology and management. International journal of nephrology and renovascular disease, 10, 35–45. https://doi.org/10.2147/IJNRD.S101808

Park, C., Obi, Y., Streja, E., Rhee, C. M., Catabay, C. J., Vaziri, N. D., Kovesdy, C. P., & Kalantar-Zadeh, K. (2017). Serum uric acid, protein intake and mortality in hemodialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(10), 1750–1757. https://doi.org/10.1093/ndt/gfw419

Patel, S. S., Molnar, M. Z., Tayek, J. A., Ix, J. H., Noori, N., Benner, D., Heymsfield, S., Kopple, J. D., Kovesdy, C. P., & Kalantar-Zadeh, K. (2013). Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature. Journal of cachexia, sarcopenia and muscle, 4(1), 19–29. https://doi.org/10.1007/s13539-012-0079-1

Peng, H., Aoieong, C., Tou, T., Tsai, T., & Wu, J. (2021). Clinical assessment of nutritional status using the modified quantified subjective global assessment and anthropometric and biochemical parameters in patients undergoing hemodialysis in Macao. The Journal of international medical research, 49(9), 3000605211045517. https://doi.org/10.1177/03000605211045517

Qian, G., Zhu, Y., Tao, S., Li, X., Liu, Z., Bai, Y., & Wang, D. (2022). Increased hemoglobin concentration and related factors in maintenance hemodialysis patients in Anhui, China. Medicine, 101(46), e31397. https://doi.org/10.1097/MD.0000000000031397

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., Shaw, J. E., Bright, D., Williams, R., & IDF Diabetes Atlas Committee (2019). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes research and clinical practice, 157, 107843. https://doi.org/10.1016/j.diabres.2019.107843

Saran, R., Robinson, B., Abbott, K. C., Bragg-Gresham, J., Chen, X., Gipson, D., Gu, H., Hirth, R. A., Hutton, D., Jin, Y., Kapke, A., Kurtz, V., Li, Y., McCullough, K., Modi, Z., Morgenstern, H., Mukhopadhyay, P., Pearson, J., Pisoni, R., Repeck, K., … Shahinian, V. (2020). US Renal Data System 2019 Annual Data Report: Epidemiology of Kidney Disease in the United States. American journal of kidney diseases : the official journal of the National Kidney Foundation, 75(1 Suppl 1), A6–A7. https://doi.org/10.1053/j.ajkd.2019.09.003

Sohrabi, Z., Eftekhari, M. H., Eskandari, M. H., Rezaeianzadeh, A., & Sagheb, M. M. (2015). Malnutrition-inflammation score and quality of life in hemodialysis patients: is there any correlation?. Nephro-urology monthly, 7(3), e27445. https://doi.org/10.5812/numonthly.7(3)2015.27445

St-Jules, D. E., Goldfarb, D. S., Pompeii, M. L., Liebman, S. E., & Sherman, R. A. (2018). Assessment and misassessment of potassium, phosphorus, and protein in the hemodialysis diet. Seminars in dialysis, 31(5), 479–486. https://doi.org/10.1111/sdi.12713

Valente, A., Caetano, C., Oliveira, T., & Garagarza, C. (2019). Evaluating haemodialysis patient's nutritional status: Body mass index or body cell mass index?. Nephrology (Carlton, Vic.), 24(9), 967–974. https://doi.org/10.1111/nep.13527

Vlaminck, H., Maes, B., Jacobs, A., Reyntjens, S., & Evers, G. (2001). The dialysis diet and fluid non-adherence questionnaire: validity testing of a self-report instrument for clinical practice. Journal of clinical nursing, 10(5), 707–715. https://doi.org/10.1046/j.1365-2702.2001.00537.x

Walther, C. P., Carter, C. W., Low, C. L., Williams, P., Rifkin, D. E., Steiner, R. W., & Ix, J. H. (2012). Interdialytic creatinine change versus predialysis creatinine as indicators of nutritional status in maintenance hemodialysis. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association, 27(2), 771–776. https://doi.org/10.1093/ndt/gfr389

World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA, 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053.