Fibra dietética como estrategia terapéutica para proteger la función de la barrera intestinal y reducir la neuroinflamación en el trastorno por uso de alcohol: implicaciones para la depresión y la recaída
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World Health Organization. Global status report on alcohol and health and treatment of substance use disorders. Geneva: WHO; 2024. Available at: https://www.who.int/publications/i/item/9789240096745
Schuckit MA. Comorbidity between substance use disorders and psychiatric conditions. Addiction. 2006;101(Suppl 1):76-88. doi: 10.1111/j.1360-0443.2006.01592.x
Briere FN, Rohde P, Seeley JR, Klein D, Lewinsohn PM. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiatry. 2014;55(3):526-533. doi: 10.1016/j.comppsych.2013.10.007
Crews FT, Lawrimore CJ, Walter TJ, Coleman LG. The role of neuroimmune signaling in alcoholism. Neuropharmacology. 2017;122:56-73. doi: 10.1016/j.neuropharm.2017.01.031
Flores-Bastias O, Karahanian E. Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system. Neuropharmacology. 2018;128:401-407. doi: 10.1016/j.neuropharm.2017.11.003
Qin L, He J, Hanes RN, Pluzarev O, Hong J-S, Crews FT. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation. 2008;5:10. doi: 10.1186/1742-2094-5-10
Perez-Reytor D, Karahanian E. Alcohol use disorder, neuroinflammation, and intake of dietary fibers: a new approach for treatment. Am J Drug Alcohol Abuse. 2023;49(3):283-289. doi: 10.1080/00952990.2022.2114005
Litwinowicz K, Choroszy M, Waszczuk E. Changes in the composition of the human intestinal microbiome in alcohol use disorder: a systematic review. Am J Drug Alcohol Abuse. 2020;46(1):4-12. doi: 10.1080/00952990.2019.1669629
Bala S, Marcos M, Gattu A, Catalano D, Szabo G. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One. 2014;9(5):e96864. doi: 10.1371/journal.pone.0096864
Silva YP, Bernardi A, Frozza RL. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front Endocrinol (Lausanne). 2020;11:25. doi: 10.3389/fendo.2020.00025
Perez-Reytor D, Puebla C, Karahanian E, Garcia K. Use of short-chain fatty acids for the recovery of the intestinal epithelial barrier affected by bacterial toxins. Front Physiol. 2021;12:650313. doi: 10.3389/fphys.2021.650313
Barbara G, Barbaro MR, Fuschi D, Palombo M, Falangone F, Cremon C, et al. Inflammatory and microbiota-related regulation of the intestinal epithelial barrier. Front Nutr. 2021;8:718356. doi: 10.3389/fnut.2021.718356
Elamin EE, Jonkers DMAE, Juuti-Uusitalo K, van IJzendoorn SCD, Troost FJ, et al. Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model. PLoS One. 2012;7:e35008. doi: 10.1371/journal.pone.0035008
Dunagan M, Chaudhry K, Samak G, Rao RK. Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1356-64. doi: 10.1152/ajpgi.00526.2011
Basuroy S, Sheth P, Mansbach CM, Rao RK. Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine. Am J Physiol Gastrointest Liver Physiol. 2005;289:G367-75. doi: 10.1152/ajpgi.00464.2004
Addolorato G, Ponziani FR, Dionisi T, Mosoni C, Vassallo GA, Sestito L, et al. Gut microbiota compositional and functional fingerprint in patients with alcohol use disorder and alcohol-associated liver disease. Liver Int. 2020;40:878-888. doi: 10.1111/liv.14383
Worthington BS, Meserole L, Syrotuck JA. Effect of daily ethanol ingestion on intestinal permeability to macromolecules. Dig Dis Sci. 1978;23(1):23-32. doi: 10.1007/BF01072571
Yang F, Wei J, Shen M, Ding Y, Lu Y, Ishaq HM, et al. Integrated analyses of the gut microbiota, intestinal permeability, and serum metabolome phenotype in rats with alcohol withdrawal syndrome. Appl Environ Microbiol. 2021;87(18):e0083421. doi: 10.1128/AEM.00834-21
Swanson GR, Garg K, Shaikh M, Keshavarzian A. Increased intestinal permeability and decreased resiliency of the intestinal barrier in alcoholic liver disease. Clin Transl Gastroenterol. 2024;15(4):e00689. doi: 10.14309/ctg.0000000000000689
Leclercq S, Matamoros S, Cani PD, Neyrinck AM, Jamar F, Starkel P, et al. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci U S A. 2014;111:E4485-93. doi: 10.1073/pnas.1415174111
Cryan JF, O'Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877-2013. doi: 10.1152/physrev.00018.2018
Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong J-S, et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia. 2007;55(5):453-462. doi: 10.1002/glia.20467
Sanchez-Alavez M, Nguyen W, Mori S, Wills DN, Otero D, Ehlers CL, et al. Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. Alcohol. 2019;76:37-45. doi: 10.1016/j.alcohol.2018.07.005
Villavicencio-Tejo F, Flores-Bastias O, Marambio-Ruiz L, Perez-Reytor D, Karahanian E. Fenofibrate (a PPAR-alpha agonist) administered during ethanol withdrawal reverts ethanol-induced astrogliosis and restores the levels of glutamate transporter in ethanol-administered adolescent rats. Front Pharmacol. 2021;12:653175. doi: 10.3389/fphar.2021.653175
Ibanez C, Acuna T, Quintanilla ME, Perez-Reytor D, Morales P, Karahanian E. Fenofibrate decreases ethanol-induced neuroinflammation and oxidative stress and reduces alcohol relapse in rats by a PPAR-alpha-dependent mechanism. Antioxidants (Basel). 2023;12(9):1758. doi: 10.3390/antiox12091758
Koob GF, Volkow ND. Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry. 2016;3(8):760-773. doi: 10.1016/S2215-0366(16)00104-8
Nestler EJ, Carlezon WA Jr. The mesolimbic dopamine reward circuit in depression. Biol Psychiatry. 2006;59(12):1151-1159. doi: 10.1016/j.biopsych.2005.09.018
Felger JC, Treadway MT. Inflammation Effects on Motivation and Motor Activity: Role of Dopamine. Neuropsychopharmacology. 2017;42(1):141-163. doi: 10.1038/npp.2016.143
DeCastro M, Nankova BB, Shah P, Patel P, Mally PV, Mishra R, La Gamma EF. Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway. Brain Res Mol Brain Res. 2005;142:28-38. doi: 10.1016/j.molbrainres.2005.09.002
Treadway MT, Zald DH. Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev. 2011;35(3):537-555. doi: 10.1016/j.neubiorev.2010.06.006
Belmer A, Patkar OL, Pitman KM, Bartlett SE. Serotonergic neuroplasticity in alcohol addiction. Brain Plast. 2016;1(2):177-206. doi: 10.3233/BPL-150022
O'Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015;277:32-48. doi: 10.1016/j.bbr.2014.07.027
Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci. 2012;13(7):465-477. doi: 10.1038/nrn3257
Leclercq S, Schwarz M, Delzenne NM, Starkel P, de Timary P. Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms. Transl Psychiatry. 2021;11:503. doi: 10.1038/s41398-021-01610-5
Leon M, Vasquez-Ulloa C, Marambio-Ruiz L, Perez-Reytor D, Karahanian E. Fenofibrate treatment during withdrawal reverses symptoms of ethanol-induced depression in male rats. Front Pharmacol. 2025;16:1626031. doi: 10.3389/fphar.2025.1626031
Isla E, Gutierrez-Vega I, Quilaqueo ME, Herrera-Marschitz M, Quintanilla ME, Morales P, et al. Fenofibrate restores glutamatergic and dopaminergic homeostasis in the nucleus accumbens and reduces alcohol relapse in rats. Front Pharmacol. 2026;17:1792426. doi: 10.3389/fphar.2026.1792426
Molendijk ML, Spinhoven P, Polak M, Bus BAA, Penninx BWJH, Elzinga BM. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol Psychiatry. 2014;19(7):791-800. doi: 10.1038/mp.2013.105
Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol. 2008;11(8):1169-1180. doi: 10.1017/S1461145708009309
Logrip ML, Janak PH, Ron D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem. 2009;109(5):1459-1468. doi: 10.1111/j.1471-4159.2009.06073.x
Heberlein A, Muschler M, Wilhelm J, Frieling H, Lenz B, Groschl M, et al. BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):1060-1064. doi: 10.1016/j.pnpbp.2010.05.025
Guan Z, Fang J. Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats. Brain Behav Immun. 2006;20(1):64-71. doi: 10.1016/j.bbi.2005.04.005
Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 2000;14(23):2919-2937. doi: 10.1101/gad.841400
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, et al. Lower synaptic density is associated with depression severity and network alterations. Nat Commun. 2019;10(1):1529. doi: 10.1038/s41467-019-09562-7
Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes. 2016;7(3):189-200. doi: 10.1080/19490976.2015.1134082
Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science. 2018;359(6380):1151-1156. doi: 10.1126/science.aao5774
Cresci GA, Glueck B, McMullen MR, Xin W, Allende D, Nagy LE. Prophylactic tributyrin treatment mitigates chronic-binge alcohol-induced intestinal barrier and liver injury. J Gastroenterol Hepatol. 2017;32:1587-1597. doi: 10.1111/jgh.13731
Cresci GA, Bush K, Nagy LE. Tributyrin supplementation protects mice from acute ethanol-induced gut injury. Alcohol Clin Exp Res. 2014;38:1489-1501. doi: 10.1111/acer.12428
Siddiqui MT, Han Y, Shapiro D, West G, Fiocchi C, Cresci GAM. The postbiotic butyrate mitigates gut mucosal disruption caused by acute ethanol exposure. Int J Mol Sci. 2024;25(3):1665. doi: 10.3390/ijms25031665
Quintanilla ME, Santapau D, Diaz E, Valenzuela Martinez I, Medina N, Landskron G, et al. Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats. Sci Rep. 2024;14:29260. doi: 10.1038/s41598-024-80228-1
Amadieu C, Coste V, Neyrinck AM, Thijssen V, Leyrolle Q, Bindels LB, et al. Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients. Gut Microbes. 2022;14:2007042. doi: 10.1080/19490976.2021.2007042
Dahl WJ, Zhu H, Guan T, Auger J, Alyousif Z, Miller JL, et al. Dietary fiber supplementation in US adults modifies gut microbiota and metabolites: a randomized, double-blind, placebo-controlled trial. J Nutr. 2023;153(12):3566-3580. doi: 10.1016/j.tjnut.2023.10.005
Baxter NT, Schmidt AW, Venkataraman A, Kim KS, Sonnenburg JL, Swann JR, et al. Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers. mBio. 2019;10(1):e02566-18. doi: 10.1128/mBio.02566-18
Reigstad CS, Salmonson CE, Rainey JF 3rd, Szurszewski JH, Linden DR, Sonnenburg JL, et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J. 2015;29(4):1395-1403. doi: 10.1096/fj.14-259598
Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, et al. The intestinal microbiota affect central levels of brain-derived neurotrophic factor and behavior in mice. Gastroenterology. 2011;141:599-609. doi: 10.1053/j.gastro.2011.04.052
Strandwitz P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018;1693(Pt B):128-133. doi: 10.1016/j.brainres.2018.03.015
Proskynitopoulos PJ, Woltemate S, Rhein M, Böke I, Molks J, Schröder S, Schneider HU, Bleich S, Frieling H, Geffers R, Glahn A, Vital M. The effect of alcohol withdrawal therapy on gut microbiota in alcohol use disorder and its link to inflammation and craving. Alcohol Clin Exp Res (Hoboken). 2025 Sep;49(9):1912-1923. doi: 10.1111/acer.70128.
Lassale C, Batty GD, Baghdadli A, Jacka F, Sanchez-Villegas A, Kivimaki M, Akbaraly T. Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Mol Psychiatry. 2019;24(7):965-986. doi: 10.1038/s41380-018-0237-8
Jacka FN, O'Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, et al. A randomised controlled trial of dietary improvement for adults with major depression (the SMILES trial). BMC Med. 2017;15:23. doi: 10.1186/s12916-017-0791-y