Oral Mucosal Melanoma: The Natural History of the Disease a Case Report
Main Article Content
Abstract
Oral Mucosal Melanoma is a very aggressive disease that requires early detection by biopsy suspicious lesions, characteristics and surgical treatment resection with wide margins, cervical lymph node dissection and adjuvant therapies aimed at eradicating systemically neoplastic cells. The aim of this report is to show the evolution of this disease in a case where the patient did not accept treatment and thus understanding its earlier stage, the subsequent invasion of adjacent tissues and finally as it spread to the cervical lymph nodes and vital organs remote triggering systemic failure.
References
Ahmadi-Motamayel, F.; Falsafi, P. & Baghaei, F. Report of a rare and aggressive case of oral malignant melanoma. Oral Maxillofac. Surg., 17(1):47-51, 2013.
Aris, M. Origen del melanocito normal y maligno. Acta Bioquim. Clin. Latinoam., 43(3):333-7, 2009.
Bakkal, F. K.; Bas man, A.; Kizil, Y.; Ekinci, Ö.; Gümüs ok, M.; Ekrem Zorlu, M. & Aydil, U. Mucosal melanoma of the head and neck: recurrence characteristics and survival outcomes. Oral Surg. Oral Med. Oral Pathol. Oral Radiol., 120(5):575-80, 2015.
Bakshi, N.; Mukherjee, S. & Chauhan, Y. S. Surgical decision making in oral mucosal melanoma with lymphadenopathy: Review of literature. Int. J. Head Neck Surg., 5(3):135-9, 2014.
Binetti, P. Más allá del consentimiento informado: la relación consensual. Cuad. Bioet., 22:509-16, 2011.
Cantín López, M.; Suazo Galdames, I.; Venegas Rojas, B. & Zavando Matamala, D. Lower lip
squamous cell carcinoma: Relationship between angiogenesis grade, histological grading and
invasion tumoral front. Int. J. Morphol., 26(1):77- 82, 2008.
Edge, S. P.; Byrd, D. R.; Compton, C. C.; Fritz, A. G.; Greene, F. L. & Trotti, A. (Eds.). Mucosal melanoma of the head and neck. A. J. C. C. Cancer Staging Manual. 7a ed. New York, Springer, 2010. pp.97-100.
Lazarev, S.; Gupta, V.; Hu, K.; Harrison, L. B. & Bakst, R. Mucosal melanoma of the head and neck: a systematic review of the literature. Int. J. Radiat. Oncol. Biol. Phys., 90(5):1108-18, 2014.
Mayer Lux, L. Autonomía del paciente y responsabilidad penal médica. Rev. Derecho Pontif. Univ. Catol. Valpso., (37):371-413, 2011.
Mohan, M.; Sukhadia, V. Y.; Pai, D. & Bhat, S. Oral malignant melanoma: systematic review of
literature and report of two cases. Oral Surg. Oral Med. Oral Pathol. Oral Radiol., 116(4): e247-54, 2013.
Morton, D. L.; Cochran, A. J.; Thompson, J. F.; Elashoff, R.; Essner, R.; Glass, E. C.; Mozzillo, N.;
Nieweg, O. E.; Roses, D. F.; Hoekstra, H. J.; Karakousis, C. P.; Reintgen, D. S.; Coventry, B. J.; Wang, H. J. & Multicenter Selective Lymphadenectomy Trial Group. Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann. Surg., 242(3):302-11, 2005.
National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in oncology (NCCN guidelines): Head and Neck Cancers. Versión 2.2011. Washington, National Comprehensive Cancer Network, 2011.
Pingarrón Martín, L.; González Martín-Moro, J.; Ma, C. Y.; Yu, Z. W. & Zhang, C. P. Melanoma de mucosa intraoral: ¿enfermedad local o sistémica? Rev. Esp. Cir. Oral Maxilofac., 36(1):15-20, 2014.
Rivera, R. D.; Diamante, M.; Kasten, S. J. & Ward, B. B. Metastatic melanoma to the mandible: case report and review of the literature. J. Oral Maxillofac. Surg., 68(11):2903-6, 2010.
Roa, I. Conceptos básicos en angiogénesis tumoral. Int. J. Med. Surg. Sci., 1(2):129-38, 2014.
Sharma, N. Primary oral malignant melanoma: two case reports and review of literature. Case Rep. Dent., 2012:975358, 2012.
Tejera-Vaquerizo, A.; Nagore, E.; Meléndez, J. J.; López-Navarro, N.; Martorell-Calatayud, A.;
Herrera-Acosta, E.; Traves, V.; Guillén, C. & Herrera-Ceballos, E. Chronology of metastasis in
cutaneous melanoma: growth rate model. J. Invest. Dermatol., 132(4):1215-21, 2012.
Weatherhead, S. C.; Haniffa, M. & Lawrence, C. M. Melanomas arising from naevi and de novo
melanomas--does origin matter? Br. J. Dermatol., 156(1):72-6, 2007.