Acute Hepatitis in a Pediatric Patient with COVID -19 : Case Report

Acute Hepatitis in a Pediatric Patient with COVID -19 : Case Report

Main Article Content

Manuel de la O-Cavazos
Manuel de la O Escamilla
Alberto Gómez-Orozco
Luis Adrían Álvarez-Lozada
Marco Antonio Flores-Heredia


COVID-19 typically courses with mild clinical manifestations; however, a pediatric patient might get severe sequelae and complications when there is an infection. There is no information about liver complications due to COVID-19 in children in Mexico. This case report will set a precedent about timely diagnosis for hepatitis as a complication for COVID-19 disease in young patients in Mexico. Clinical case: A 12-years-old man has intermittent generalized abdominal pain misdiagnosed and treated for irritable bowel syndrome 3 days prior. The abdominal pain stayed, and a day after the patient vomited 3 times (each one after every meal). The patient started with orangish urine, weakness, fatigue and hyporexia 1 day prior to admission. The day of the admittance, a COVID-19 RT-PCR test was performed, giving a positive result. Once he was admitted, laboratory tests were made, showing an increase of liver                               enzyme levels, showing liver disease as a complication for the viral infection. Conclusion: Pediatrics patients might get Hepatitis due to COVID-19. In a patient with abdominal pain or other liver disease symptoms while coursing with the virus or even after the infection, further investigation must be made.


Ali, S., Prakash, S., & Murali, A. R. (2021). Hepatic Manifestations of Nonhepatotropic Infectious Agents Including Severe Acute Respiratory

Syndrome Coronavirus-2, Adenovirus, Herpes Simplex Virus, and Coxiella burnetii. Gastroenterology clinics of North America, 50(2), 383–402.

Antala, S., Diamond, T., Kociolek, L. K., Shah, A. A., & Chapin, C. A. (2022). Severe Hepatitis in Pediatric COVID-19. Journal of pediatric gastroenterology and nutrition.

CONACYT. (2022, 14 marzo). COVID-19 Tablero México. COVID - 19 Tablero México. Recuperado 15 de marzo de 2022, de

Couture, A., Lyons, B. C., Mehrotra, M. L., Sosa, L., Ezike, N., Ahmed, F. S., Brown, C. M., Yendell, S., Azzam, I. A., Katić, B. J., Cope, A., Dickerson, K., Stone, J., Traxler, L. B., Dunn, J. R., Davis, L. B., Reed, C., Clarke, K., Flannery, B., & Charles, M. D. (2022). Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Reported Coronavirus Disease 2019

Cases in US Children, August 2020-May 2021. Open forum infectious diseases, 9(3), ofac044.

Cui X, Zhao Z, Zhang T, Guo W, Guo W, Zheng J, Zhang J, Dong C, Na R, Zheng L, Li W, Liu Z, Ma J, Wang J, He S, Xu Y, Si P, Shen Y, Cai C. A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19), J Med Virol. 2021;93(2):1057-1069. DOI: 10.1002/jmv.26398

Herrera, C., Betancourt Cervantes, J., Lage Dávila, A. ., Barreto Fiu , E., Sánchez Valdés , L., Chávez González, E., & Caballero López , A. (2021). Variables associated with severity in COVID-19 patients . International Journal of Medical and Surgical Sciences, 8(3), 1–15.

León Gómez, J., Gómez Aldana, A. J., & Tapias Mantilla, M. L. (2020). Implicaciones hepáticas en la pandemia por COVID-19. Revista Colombiana De Gastroenterología, 35(Supl. 1), 30-36.

Nikolopoulou, G. B., & Maltezou, H. C. (2022). COVID-19 in Children: Where do we Stand?. Archives of medical research, 53(1), 1–8.

Patel N. A. (2020). Pediatric COVID-19: Systematic review of the literature. American journal of otolaryngology, 41(5), 102573.

Pedreañez, A., Mosquera-Sulbarán, J. ., Muñoz, N., Tene, D., & Robalino, J. . (2021). The disadvantage of men against COVID-19. Analysis of the influence of sex on the immune response to SARS-CoV-2 infection. International Journal of Medical and Surgical Sciences, 8(3), 1–18.

Peramo-Álvarez, F. P., López-Zúñiga, M. Á., & López-Ruz, M. Á. (2021). Medical sequels of COVID-19. Medicina clinica (English ed.), 157(8), 388–394.

Pokorska-Śpiewak, M., & Śpiewak, M. (2020). Management of hepatitis C in children and adolescents during COVID-19 pandemic. World journal of hepatology, 12(8), 485–492.

U.S. Food & Drugs Administration. (2021, 2 julio). Coronavirus (COVID-19) | Drugs. U.S. Food and Drug Administration. Recuperado 23 de marzo de 2022, de 19-drugs

Wang, D., Ju, X. L., Xie, F., Lu, Y., Li, F. Y., Huang, H. H., Fang, X. L., Li, Y. J., Wang, J. Y., Yi, B., Yue, J. X., Wang, J., Wang, L. X., Li, B., Wang, Y., Qiu, B. P., Zhou, Z. Y., Li, K. L., Sun, J. H., Liu, X. G., … Chen, Y. N. (2020). Zhonghua er ke za zhi = Chinese journal of pediatrics, 58(4), 269–274.

Yang, R. X., Zheng, R. D., & Fan, J. G. (2020). Etiology and management of liver injury in patients with COVID-19. World journal of gastroenterology, 26(32), 4753–4762.