Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides.

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Published: Dec 1, 2017
DOI: https://doi.org/10.32457/ijmss.2017.031
Keywords:
insecticides, DD-Force, Baygon, exposure, renal damage

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How to Cite
Nwankwo, V., Uraku, A., Famurewa, A., & Uraku, O. (2017). Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides. International Journal of Medical and Surgical Sciences, 4(4), 1251–1258. https://doi.org/10.32457/ijmss.2017.031
Issue
Vol. 4 No. 4 (2017): December 2017
Section
Research Article

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Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides.

Main Article Content

Victor Nwankwo
Department of Biotechnology, Ebonyi State University, PMB 053 Abakaliki, Ebonyi State.
Anayo Uraku
Department of Biochemistry, Ebonyi State University, PMB 053 Abakaliki, Ebonyi State.
Ademola Famurewa
Department of Medical Biochemistry, Federal University Ndufu-Alike, Ikwo, Ebonyi State.
Oluchi Uraku
Department of Biochemistry, Ebonyi State University, PMB 053 Abakaliki, Ebonyi State.

Abstract

Although studies suggest adverse effects of pesticides, human exposure to insecticides in homes is increasing and reports on their health effects are limited. The study investigated nephrotoxic effects of organo phosphate and carbamate insecticides, DD-Force and Baygon, in albino rats. Forty-five albino rats divided into groups were exposed to DD-Force (dichlorvos) or Baygon (propoxur) indoor insecticidein wooden boxes in separate exposure duration of 1, 2, 3 and 4 hours/day for 14 consecutive days. Serum and kidney tissue obtained after sacrifice were used to determine markers of renal damage and histopathological analysis, respectively. Exposure of rats to the insecticides showed duration-dependent significant increases (p<0.05) in serum levels of urea, uric acid and creatinine compared to control. However, rats exposed to DD-Force insecticide induced significantly higher levels of urea, uric acid and creatinine compared to Baygon (p<0.05). Histopathological lesions were observed in rats exposed to the insecticides, particularly in the exposure duration of 3 or 4 hours/day. These findings suggest that acute exposure to DD-Force and Baygonis nephrotoxic and may induce renal damage in rats.

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