Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides.

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Publicado: dic 1, 2017
DOI: https://doi.org/10.32457/ijmss.2017.031

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Nwankwo, V., Uraku, A., Famurewa, A., & Uraku, O. (2017). Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides. International Journal of Medical and Surgical Sciences, 4(4), 1251–1258. https://doi.org/10.32457/ijmss.2017.031
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Vol. 4 Núm. 4 (2017): December 2017
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Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides.

Contenido principal del artículo

Victor Nwankwo
Department of Biotechnology, Ebonyi State University, PMB 053 Abakaliki, Ebonyi State.
Anayo Uraku
Department of Biochemistry, Ebonyi State University, PMB 053 Abakaliki, Ebonyi State.
Ademola Famurewa
Department of Medical Biochemistry, Federal University Ndufu-Alike, Ikwo, Ebonyi State.
Oluchi Uraku
Department of Biochemistry, Ebonyi State University, PMB 053 Abakaliki, Ebonyi State.

Resumen

Although studies suggest adverse effects of pesticides, human exposure to insecticides in homes is increasing and reports on their health effects are limited. The study investigated nephrotoxic effects of organo phosphate and carbamate insecticides, DD-Force and Baygon, in albino rats. Forty-five albino rats divided into groups were exposed to DD-Force (dichlorvos) or Baygon (propoxur) indoor insecticidein wooden boxes in separate exposure duration of 1, 2, 3 and 4 hours/day for 14 consecutive days. Serum and kidney tissue obtained after sacrifice were used to determine markers of renal damage and histopathological analysis, respectively. Exposure of rats to the insecticides showed duration-dependent significant increases (p<0.05) in serum levels of urea, uric acid and creatinine compared to control. However, rats exposed to DD-Force insecticide induced significantly higher levels of urea, uric acid and creatinine compared to Baygon (p<0.05). Histopathological lesions were observed in rats exposed to the insecticides, particularly in the exposure duration of 3 or 4 hours/day. These findings suggest that acute exposure to DD-Force and Baygonis nephrotoxic and may induce renal damage in rats.

Citas

AAbdu, I.T., Adamu, L.H., Modibbo, M.H. & Yusuf, A.A. Effect of dichlorvos on histoarchitecture of the cerebral blood vessels in adult wistar rats. Journal of Neurobehavioral Sciences., 3(1):7-12, 2016.

Akunyili, D (2007). Otapiapia’ not registered with NAFDAC in Daily Triumph Newspaper. [Available at: http://www.triumphnewspapers.com/].

Aldana, L., Tsutsumi, V., Craigmill, A., Silveira, M.I. & González de Mejía, E. alpha-Tocopherol modulates liver toxicity of the pyrethroid cypermethrin. Toxicol. Lett., 125(1-3):107-16, 2001.

Atherton, K.M., Williamson, F.M., Jameson, S.J. & Mutch, E.M. DNA damage by dichlorvos and repair profiles in human lymphocytes, in vitro. Toxicology., 226(1):53, 2006.

Banerjee, B.D., Seth, V., Bhattacharya, A., Pasha, S.T. & Chakraborty, A.K. Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers. Toxicol. Lett., 107(1-3):33-47., 1999.

Begum, G. Carbofuran insecticide induced biochemical alterations in liver and muscle tissues of the fish Clarias batrachus (linn) and recovery response. Aquat. Toxicol., 66(1):83-92, 2004.

Bohmont, B. L. (1990). The Students’ Pesticide Users Guide. 8th edition. Prentice-Hall Inc., London, 170-221.

Doherty, V.F., Ladipo, M.K., Aneyo, I.A., Adeola, A. & Odulele, W.Y. Histopathological alterations, biochemical responses and acetylcholinesterase levels in Clariasgariepinusas biomarkers of exposure to organophosphates pesticides. Environ. Monit. Assess., 188(5):312, 2016.

Igwenyi, I.O., Aboh, N., Nwachukwu, N., Ibiam, U.A., Offor, C.E., Aja, P.M. & Agbafor, K.N. Effect of baygoninsecticide on the activities of total, alkaline and acid phosphatases of selected tissues of albino rats. J. Pharm. Biol. Sci., 9(3):41-3, 2014.

Institóris, L., Papp, A., Siroki, O., Banerjee, B.D. & Dési, I. Immuno- and neurotoxicological investigation of combined subacute exposure with the carbamate pesticide propoxur and cadmium in rats. Toxicology., 178:161–73, 2002.

Kolawole, O.T & Asaolu, O. S. Mothers’ socioeconomic differentials and management of malaria in Nigeria. SAGE Open: 1– 9, 2016.

Lukaszewicz-Hussain, A. Role of oxidative stress in organophosphate insecticide toxicity – Short review. Pest. Biochem. Physiol., 98: 145–50, 2010.

Mundhe, A.Y. & Pandit, S.V. Assessment of Toxicity of Monocrotophos in Freshwater Bivalve, Lamellidens marginalis, Using Different Markers. Toxicol. Int., 21(1): 51-6, 2014.

Musa, U., Hati, S.S., Mustapha, A. & Magaji, G. Dichlorvos concentrations in locally formulated pesticide (Ota-piapia) utilized in northeastern Nigeria. Sci. Res. Essay., 5(1): 49-54, 2010.

Naggayi, M., Mukiibi, N. & Iliya, E. The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male wistar rats. Afr. Health. Sci., 15(2): 598-605, 2015.

Ngoula, F., Watcho, P., Bouseko, T.S., Kenfack, A., Tchoumboué, J. & Kamtchouing, P. Effects of propoxur on the reproductive system of male rats. Afr. J. Reprod. Health., 11(1):125-32, 2007.

Okokon, J.E., Nwafor, P.A., & Noah, K. Nephroprotective effect of Croton zambesicus root extract against gentimicin-induced kidney injury. Asian. Pac. J. Trop. Med.,4(12):969-72, 2011.

Proctor, S.P., Heaton, K.J., Heeren, T., & White, R.F. Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans. Neurotoxicology., 27(6):931-9,2006.

Rastogi, S.K., Satyanarayan, P.V., Ravishanker, D., & Tripathi, S.A study on oxidative stress and antioxidant status of agricultural workers exposed to organophosphorus insecticides during spraying. Indian. J. Occup. Environ. Med., 13(3): 131-34, 2009.

Rekha, S.R. & Sajad, H. Histopathological effects of pesticide-cholopyrifos on kidney in albino rats. Int. J. Res. Med. Sci., 1(4):465-75, 2013.

Sarin, S., & Gill, K.D. Dichlorvos induced alterations in glucose homeostasis: Possible implications on the state of neuronal function in rats. Mol. Cell. Biochem., 199:87-92, 1999.

Tsitsimpikou, C., Tzatzarakis, M., Fragkiadaki, P., Kovatsi, L., Stivaktakis, P., Kalogeraki, A., Kouretas, D. & Tsatsakis, A.M. Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur. Toxicology., 10;307:109-14, 2013.

Uthman, G.S., Aminu, N.A., Musa, H.A., Ahmad, M.A., Musa, A.B., Wazis, H.C., Zezi. A. & Timothy, S.Y. Biochemical and Histopathologic Changes in Liver of Albino Rats Exposed to 1% Dichlorvos Pesticide at Sub-Acute Period. J. Pharm. Biomed. Sci., 3(2): 1-6, 2013.

International Programme on Chemical Safety, The WHO recommended classification of pesticides by hazard and guidelines to classification 1994- 1995, UNEP/ILO/WHO 1994.

Yaman, I. & Balikci, E. Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats. 62: 183–190, 2010. Exp. Toxicol. Pathol., 62(2):183-90, 2010.

Yassin, M.M, & Al-Shanti, T.A. Effect of pesticides on kidney function and serum protein profile of farm workers in Gaza Strip. AMBS., 2(1): 21-7, 2015