Studies of dietary phytoestrogen from momordica charantia Linn. Seeds
Main Article Content
Abstract
Phytoestrogens are secondary plant metabolites produced by plants that are similar in structure of estrogen. Human consumption of these compounds has been associated with many health benefits. In this study, we investigated the potential phytoestrogen content of dietary Momordica charantia Linn. (Bitter melon) seeds were collected from the Hyderabad-Karnataka regions of India.
A phenolic dietary phytoestrogen has been isolated from the crude ethanol extract of Bitter melon seeds. After preparative HPLC whitish amorphous compound was yielded. The HPLC purified compound is subjected to spectral analysis using IR, NMR and MS. The spectral data revealed that the phenolphthalein a phytoestrogenic molecule is present in the ethanol extract of dietary Bitter melon seeds.
References
Adlercreutz H, Phytoestrogens: epidemiology and a possible role in cancer protection. In: McLachlan JA, Korach KS, eds. Estrogens in the environment, III: global health implications, Environmental Health Perspectives, 1995, 103(Suppl 7), 103–112.
Kronenberg F, Fugh-Berman A, Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trails, Annals of Internal Medicine, 2002, 137, 805-813.
Kumar Shetty A, Suresh Kumar G, Veerayya Salimath P, Bitter gourd (Momordica charantia) modulates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats, Molecular Nutrition and Food Research, 2005,49(8), 791–796.
Liu J, Burdette JE, Xu H et al., Evaluation of oestrogenic activity of plant extracts for the potential treatment on menopausal symptoms, Journal of Agricultural Food Chemistry, 2001b, 49, 2472-2479.
Nelson L, Menstruation and the menstrual cycle fact sheet, Women’s Health, National Institutes of Health, 21 Oct 2009. Web. 8 Nov 2011.
Nerurkar PV, Lee YK, Motosue M, Adeli K, Nerurkar VR, Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and inrcreases hepatic insulin receptor 11 substrate and phosphoinositide-3 kinase interactions, British Journal of Nutrition, 2008, 100(4), 751-759.
Oishi Y, Sakamoto T, Udagawa H, Taniguchi H, Kobayashi-Hattori K, Ozawa Y, Takita T, Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction, Bioscience, Biotechnology and Biochemstry, 2007, 71(3), 735-740.
Patil SA, Patil SB, Toxicological studies of Momordica charantia Linn. Seed extracts in male mice, International Journal of Morphology, 2011, 29(4), 1212-1218.
Sharanabasappa AP, Vijaykumar B, Saraswati BP, Effect of Momordica charantia seed extracts on ovarian and uterine activities in albino rats, Pharmaceutical Biology, 2002, 40, 501-507.
Sharanabasappa AP, Saraswati BP, Contraceptive potential of phenolphthalein isolated from the seeds of Momordica charantia (Cucurbitaceae), Asian Journal of Pharmacodynamics and Pharmacokinetics, 2010, 10(1), 53-58.
Singh J, Adeghate E, Cummings E, Giannikipolous C, Sharma AK, Ahmed I, Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat, Molecular and Cellular Biochemistry, 2004, 261(1-2), 63-70.
Warren, Barbour, Carol D, Phytoestrogens and Breast Cancer, Breast Cancer and Environmental Risk Factors, Cornell University, 07 2001. Web. 8 Nov 2011.
Zieve D, Susan S, Menopause, Pub Med Health, National Institutes of Health, 11 09 2010. Web. 8 Nov 2011.